Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)
1_MELSA 6_ VGERV 11_ FAAEA 16_ LLKRR 21_ IRKGR 26_ MEYLV 31_ KWKGW 36_ SQKYS 41_ TWEPE 46_ ENILD 51_ ARLLA 56_ AFEER 61_ EREME 66_ LYGPK 71_ KRGPK 76_ PKTFL 81_ LKAQA 86_ KAKAK 91_ TYEFR 96_ SDSAR 101_ GIRIP 106_ YPGRS 111_ PQDLA 116_ STSRA 121_ REGLR 126_ NMGLS 131_ PPASS 136_ TSTSS 141_ TCRAE 146_ APRDR 151_ DRDRD 156_ RDRER 161_ DRERE 166_ RERER 171_ ERERE 176_ RERER 181_ GTSRV 186_ DDKPS 191_ SPGDS 196_ SKKRG 201_ PKPRK 206_ ELPDP 211_ SQRPL 216_ GEPSA 221_ GLGEY 226_ LKGRK 231_ LDDTP 236_ SGAGK 241_ FPAGH 246_ SVIQL 251_ ARRQD 256_ SDLVQ 261_ CGVTS 266_ PSSAE 271_ ATGKL 276_ AVDTF 281_ PARVI 286_ KHRAA 291_ FLEAK 296_ GQGAL 301_ DPNGT 306_ RVRHG 311_ SGPPS 316_ SGGGL 321_ YRDMG 326_ AQGGR 331_ PSLIA 336_ RIPVA 341_ RILGD 346_ PEEES 351_ WSPSL 356_ TNLEK 361_ VVVTD 366_ VTSNF 371_ LTVTI 376_ KESNT 381_DQGFF
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility