Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2)
1_MYRWL 6_ VRILG 11_ TIFRF 16_ CDRSV 21_ PPARA 26_ LLKRR 31_ RSDST 36_ LFSTV 41_ DTDEI 46_ PAKRP 51_ RLDCF 56_ IHQVK 61_ NSLYN 66_ AASLF 71_ GFPFQ 76_ LTTKP 81_ MVTSA 86_ CNGTR 91_ NVAPS 96_ GEVFS 101_ NSSSC 106_ ELTGS 111_ GSWNN 116_ MLKLG 121_ NKSPN 126_ GISDY 131_ PKIRV 136_ TVTRD 141_ QPRRV 146_ LPSFG 151_ FTLNS 156_ EGCNR 161_ RPGGR 166_ RHSKG 171_ NPESS 176_ LMWKP 181_ QEQAV 186_ TEMIS 191_ EESGK 196_ GLRRP 201_ HCTVE 206_ EGVQK 211_ EEREK 216_ YRKLL 221_ ERLKE 226_ SGHGN 231_ SVCPV 236_ TSNYH 241_ SSQRS 246_ QMDTL 251_ KTKGW 256_ GEEQN 261_ HGVKT 266_ TQFVP 271_ KQYRL 276_ VETRG 281_ PLCSL 286_ RSEKR 291_ CSKGK 296_ ITDTE 301_ TMVGI 306_ RFENE 311_ SRRGY 316_ QLEPD 321_ LSEEV 326_ SARLR 331_ LGSGS 336_ NGLLR 341_ RKVSI 346_ IETKE 351_ KNCSG 356_ KERDR 361_ RTDDL 366_ LELTE 371_ DMEKE 376_ ISNAL 381_ GHGPQ 386_ DEILS 391_ SAFKL 396_ RITRG 401_ DIQTL 406_ KNYHW 411_ LNDEV 416_ INFYM 421_ NLLVE 426_ RNKKQ 431_ GYPAL 436_ HVFST 441_ FFYPK 446_ LKSGG 451_ YQAVK 456_ RWTKG 461_ VNLFE 466_ QEIIL 471_ VPIHR 476_ KVHWS 481_ LVVID 486_ LRKKC 491_ LKYLD 496_ SMGQK 501_ GHRIC 506_ EILLQ 511_ YLQDE 516_ SKTKR 521_ NSDLN 526_ LLEWT 531_ HHSMK 536_ PHEIP 541_ QQLNG 546_ SDCGM 551_ FTCKY 556_ ADYIS 561_ RDKPI 566_ TFTQH 571_ QMPLF 576_ RKKMV 581_WEILH
1: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:15296745, PubMed:20194620, PubMed:21965678). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15296745, PubMed:20194620, PubMed:21965678). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity)