Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512)
1_MAGQP 6_ GHMPH 11_ GGSSN 16_ NLCHT 21_ LGPVH 26_ PPDPQ 31_ RHPNT 36_ LSFRC 41_ SLADF 46_ QIEKK 51_ IGRGQ 56_ FSEVY 61_ KATCL 66_ LDRKT 71_ VALKK 76_ VQIFE 81_ MMDAK 86_ ARQDC 91_ VKEIG 96_ LLKQL 101_ NHPNI 106_ IKYLD 111_ SFIED 116_ NELNI 121_ VLELA 126_ DAGDL 131_ SQMIK 136_ YFKKQ 141_ KRLIP 146_ ERTVW 151_ KYFVQ 156_ LCSAV 161_ EHMHS 166_ RRVMH 171_ RDIKP 176_ ANVFI 181_ TATGV 186_ VKLGD 191_ LGLGR 196_ FFSSE 201_ TTAAH 206_ SLVGT 211_ PYYMS 216_ PERIH 221_ ENGYN 226_ FKSDI 231_ WSLGC 236_ LLYEM 241_ AALQS 246_ PFYGD 251_ KMNLF 256_ SLCQK 261_ IEQCD 266_ YPPLP 271_ GEHYS 276_ EKLRE 281_ LVSMC 286_ ICPDP 291_ HQRPD 296_ IGYVH 301_ QVAKQ 306_MHIWM
1: Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757)