Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein)
1_MPSKF 6_ SCRQL 11_ REAGQ 16_ CFESF 21_ LVVRG 26_ LDMET 31_ DRERL 36_ RTIYN 41_ RDFKI 46_ SFGTP 51_ APGFS 56_ SMLYG 61_ MKIAN 66_ LAYVT 71_ KTRVR 76_ FFRLD 81_ RWADV 86_ RFPEK 91_ RRMKL 96_ GSDIS 101_ KHHKS 106_ LLAKI 111_ FYDRA 116_ EYLHG 121_ KHGVD 126_ VEVQG 131_ PHEAR 136_ DGQLL 141_ IRLDL 146_ NRKEV 151_ LTLRL 156_ RNGGT 161_ QSVTL 166_ THLFP 171_ LCRTP 176_ QFAFY 181_ NEDQE 186_ LPCPL 191_ GPGEC 196_ YELHV 201_ HCKTS 206_ FVGYF 211_ PATVL 216_ WELLG 221_ PGESG 226_ SEGAG 231_ TFYIA 236_ RFLAA 241_ VAHSP 246_ LAAQL 251_ KPMTP 256_ FKRTR 261_ ITGNP 266_ VVTNR 271_ IEEGE 276_ RPDRA 281_ KGYDL 286_ ELSMA 291_ LGTYY 296_ PPPRL 301_ RQLLP 306_ MLLQG 311_ TSIFT 316_ APKEI 321_ AEIKA 326_ QLETA 331_ LKWRN 336_ YEVKL 341_ RLLLH 346_ LEELQ 351_ MEHDI 356_ RHYDL 361_ ESVPM 366_ TWDPV 371_ DQNPR 376_ LLTLE 381_ VPGVT 386_ ESRPS 391_ VLRGD 396_ HLFAL 401_ LSSET 406_ HQEDP 411_ ITYKG 416_ FVHKV 421_ ELDRV 426_ KLSFS 431_ MSLLS 436_ RFVDG 441_ LTFKV 446_ NFTFN 451_ RQPLR 456_ VQHRA 461_ LELTG 466_ RWLLW 471_ PMLFP 476_ VAPRD 481_ VPLLP 486_ SDVKL 491_ KLYDR 496_ SLESN 501_ PEQLQ 506_ AMRHI 511_ VTGTT 516_ RPAPY 521_ IIFGP 526_ PGTGK 531_ TVTLV 536_ EAIKQ 541_ VVKHL 546_ PKAHI 551_ LACAP 556_ SNSGA 561_ DLLCQ 566_ RLRVH 571_ LPSSI 576_ YRLLA 581_ PSRDI 586_ RMVPE 591_ DIKPC 596_ CNWDA 601_ KKGEY 606_ VFPAK 611_ KKLQE 616_ YRVLI 621_ TTLIT 626_ AGRLV 631_ SAQFP 636_ IDHFT 641_ HIFID 646_ EAGHC 651_ MEPES 656_ LVAIA 661_ GLMEV 666_ KETGD 671_ PGGQL 676_ VLAGD 681_ PRQLG 686_ PVLRS 691_ PLTQK 696_ HGLGY 701_ SLLER 706_ LLTYN 711_ SLYKK 716_ GPDGY 721_ DPQFI 726_ TKLLR 731_ NYRSH 736_ PTILD 741_ IPNQL 746_ YYEGE 751_ LQACA 756_ DVVDR 761_ ERFCR 766_ WAGLP 771_ RQGFP 776_ IIFHG 781_ VMGKD 786_ EREGN 791_ SPSFF 796_ NPEEA 801_ ATVTS 806_ YLKLL 811_ LAPSS 816_ KKGKA 821_ RLSPR 826_ SVGVI 831_ SPYRK 836_ QVEKI 841_ RYCIT 846_ KLDRE 851_ LRGLD 856_ DIKDL 861_ KVGSV 866_ EEFQG 871_ QERSV 876_ ILIST 881_ VRSSQ 886_ SFVQL 891_ DLDFN 896_ LGFLK 901_ NPKRF 906_ NVAVT 911_ RAKAL 916_ LIIVG 921_ NPLLL 926_ GHDPD 931_ WKVFL 936_ EFCKE 941_ NGGYT 946_ GCPFP 951_ AKLDL 956_ QQGQN 961_ LLQGL 966_ SKLSP 971_ STSGP 976_ HSHDY 981_ LPQER 986_ EGEGG 991_ LSLQV 996_EPEWR
1: 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324)
2: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription