E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
1_MSNPG 6_ TRRNG 11_ SSIKI 16_ RLTVL 21_ CAKNL 26_ AKKDF 31_ FRLPD 36_ PFAKI 41_ VVDGS 46_ GQCHS 51_ TDTVK 56_ NTLDP 61_ KWNQH 66_ YDLYV 71_ GKTDS 76_ ITISV 81_ WNHKK 86_ IHKKQ 91_ GAGFL 96_ GCVRL 101_ LSNAI 106_ SRLKD 111_ TGYQR 116_ LDLCK 121_ LNPSD 126_ TDAVR 131_ GQIVV 136_ SLQTR 141_ DRIGT 146_ GGSVV 151_ DCRGL 156_ LENEG 161_ TVYED 166_ SGPGR 171_ PLSCF 176_ MEEPA 181_ PYTDS 186_ TGAAA 191_ GGGNC 196_ RFVES 201_ PSQDQ 206_ RLQAQ 211_ RLRNP 216_ DVRGS 221_ LQTPQ 226_ NRPHG 231_ HQSPE 236_ LPEGY 241_ EQRTT 246_ VQGQV 251_ YFLHT 256_ QTGVS 261_ TWHDP 266_ RIPSP 271_ SGTIP 276_ GGDAA 281_ FLYEF 286_ LLQGH 291_ TSEPR 296_ DLNSV 301_ NCDEL 306_ GPLPP 311_ GWEVR 316_ STVSG 321_ RIYFV 326_ DHNNR 331_ TTQFT 336_ DPRLH 341_ HIMNH 346_ QCQLK 351_ EPSQP 356_ LPLPS 361_ EGSLE 366_ DEELP 371_ AQRYE 376_ RDLVQ 381_ KLKVL 386_ RHELS 391_ LQQPQ 396_ AGHCR 401_ IEVSR 406_ EEIFE 411_ ESYRQ 416_ IMKMR 421_ PKDLK 426_ KRLMV 431_ KFRGE 436_ EGLDY 441_ GGVAR 446_ EWLYL 451_ LCHEM 456_ LNPYY 461_ GLFQY 466_ STDNI 471_ YMLQI 476_ NPDSS 481_ INPDH 486_ LSYFH 491_ FVGRI 496_ MGLAV 501_ FHGHY 506_ INGGF 511_ TVPFY 516_ KQLLG 521_ KPIQL 526_ SDLES 531_ VDPEL 536_ HKSLV 541_ WILEN 546_ DITPV 551_ LDHTF 556_ CVEHN 561_ AFGRI 566_ LQHEL 571_ KPNGR 576_ NVPVT 581_ EENKK 586_ EYVRL 591_ YVNWR 596_ FMRGI 601_ EAQFL 606_ ALQKG 611_ FNELI 616_ PQHLL 621_ KPFDQ 626_ KELEL 631_ IIGGL 636_ DKIDL 641_ NDWKS 646_ NTRLK 651_ HCVAD 656_ SNIVR 661_ WFWQA 666_ VETFD 671_ EERRA 676_ RLLQF 681_ VTGST 686_ RVPLQ 691_ GFKAL 696_ QGSTG 701_ AAGPR 706_ LFTIH 711_ LIDAN 716_ TDNLP 721_ KAHTC 726_ FNRID 731_ IPPYE 736_ SYEKL 741_ YEKLL 746_ TAVEE 751_TCGFA
1: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (PubMed:21791611). Plays a role in dendrite formation by melanocytes (PubMed:23999003)