Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2)
1_MPEPW 6_ GTVYF 11_ LGIAQ 16_ VFSFL 21_ FSWWN 26_ LEGVM 31_ NQADA 36_ PRPLN 41_ WTIRK 46_ LCHAA 51_ FLPSV 56_ RLLKA 61_ QKSWI 66_ ERAFY 71_ KRECV 76_ HIIPS 81_ TKDPH 86_ RCCCG 91_ RLIGQ 96_ HVGLT 101_ PSISV 106_ LQNEK 111_ NESRL 116_ SRNDI 121_ QSEKW 126_ SISKH 131_ TQLSP 136_ TDAFG 141_ TIEFQ 146_ GGGHS 151_ NKAMY 156_ VRVSF 161_ DTKPD 166_ LLLHL 171_ MTKEW 176_ QLELP 181_ KLLIS 186_ VHGGL 191_ QNFEL 196_ QPKLK 201_ QVFGK 206_ GLIKA 211_ AMTTG 216_ AWIFT 221_ GGVNT 226_ GVIRH 231_ VGDAL 236_ KDHAS 241_ KSRGK 246_ ICTIG 251_ IAPWG 256_ IVENQ 261_ EDLIG 266_ RDVVR 271_ PYQTM 276_ SNPMS 281_ KLTVL 286_ NSMHS 291_ HFILA 296_ DNGTT 301_ GKYGA 306_ EVKLR 311_ RQLEK 316_ HISLQ 321_ KINTR 326_ CLPFF 331_ SLDSR 336_ LFYSF 341_ WGSCQ 346_ LDSVG 351_ IGQGV 356_ PVVAL 361_ IVEGG 366_ PNVIS 371_ IVLEY 376_ LRDTP 381_ PVPVV 386_ VCDGS 391_ GRASD 396_ ILAFG 401_ HKYSE 406_ EGGLI 411_ NESLR 416_ DQLLV 421_ TIQKT 426_ FTYTR 431_ TQAQH 436_ LFIIL 441_ MECMK 446_ KKELI 451_ TVFRM 456_ GSEGH 461_ QDIDL 466_ AILTA 471_ LLKGA 476_ NASAP 481_ DQLSL 486_ ALAWN 491_ RVDIA 496_ RSQIF 501_ IYGQQ 506_ WPVGS 511_ LEQAM 516_ LDALV 521_ LDRVD 526_ FVKLL 531_ IENGV 536_ SMHRF 541_ LTISR 546_ LEELY 551_ NTRHG 556_ PSNTL 561_ YHLVR 566_ DVKKG 571_ NLPPD 576_ YRISL 581_ IDIGL 586_ VIEYL 591_ MGGAY 596_ RCNYT 601_ RKRFR 606_ TLYHN 611_ LFGPK 616_ RPKAL 621_ KLLGM 626_ EDDIP 631_ LRRGR 636_ KTTKK 641_ REEEV 646_ DIDLD 651_ DPEIN 656_ HFPFP 661_ FHELM 666_ VWAVL 671_ MKRQK 676_ MALFF 681_ WQHGE 686_ EAMAK 691_ ALVAC 696_ KLCKA 701_ MAHEA 706_ SENDM 711_ VDDIS 716_ QELNH 721_ NSRDF 726_ GQLAV 731_ ELLDQ 736_ SYKQD 741_ EQLAM 746_ KLLTY 751_ ELKNW 756_ SNATC 761_ LQLAV 766_ AAKHR 771_ DFIAH 776_ TCSQM 781_ LLTDM 786_ WMGRL 791_ RMRKN 796_ SGLKV 801_ ILGIL 806_ LPPSI 811_ LSLEF 816_ KNKDD 821_ MPYMS 826_ QAQEI 831_ HLQEK 836_ EAEEP 841_ EKPTK 846_ EKEEE 851_ DMELT 856_ AMLGR 861_ NNGES 866_ SRKKD 871_ EEEVQ 876_ SKHRL 881_ IPLGR 886_ KIYEF 891_ YNAPI 896_ VKFWF 901_ YTLAY 906_ IGYLM 911_ LFNYI 916_ VLVKM 921_ ERWPS 926_ TQEWI 931_ VISYI 936_ FTLGI 941_ EKMRE 946_ ILMSE 951_ PGKLL 956_ QKVKV 961_ WLQEY 966_ WNVTD 971_ LIAIL 976_ LFSVG 981_ MILRL 986_ QDQPF 991_ RSDGR 996_ VIYCV 1001_ NIIYW 1006_ YIRLL 1011_ DIFGV 1016_ NKYLG 1021_ PYVMM 1026_ IGKMM 1031_ IDMMY 1036_ FVIIM 1041_ LVVLM 1046_ SFGVA 1051_ RQAIL 1056_ FPNEE 1061_ PSWKL 1066_ AKNIF 1071_ YMPYW 1076_ MIYGE 1081_ VFADQ 1086_ IDPPC 1091_ GQNET 1096_ REDGK 1101_ IIQLP 1106_ PCKTG 1111_ AWIVP 1116_ AIMAC 1121_ YLLVA 1126_ NILLV 1131_ NLLIA 1136_ VFNNT 1141_ FFEVK 1146_ SISNQ 1151_ VWKFQ 1156_ RYQLI 1161_ MTFHE 1166_ RPVLP 1171_ PPLII 1176_ FSHMT 1181_ MIFQH 1186_ LCCRW 1191_ RKHES 1196_ DPDER 1201_ DYGLK 1206_ LFITD 1211_ DELKK 1216_ VHDFE 1221_ EQCIE 1226_ EYFRE 1231_ KDDRF 1236_ NSSND 1241_ ERIRV 1246_ TSERV 1251_ ENMSM 1256_ RLEEV 1261_ NEREH 1266_ SMKAS 1271_ LQTVD 1276_ IRLAQ 1281_ LEDLI 1286_ GRMAT 1291_ ALERL 1296_ TGLER 1301_ AESNK 1306_ IRSRT 1311_ SSDCT 1316_ DAAYI 1321_ VRQSS 1326_ FNSQE 1331_ GNTFK 1336_ LQESI 1341_ DPAGE 1346_ ETMSP 1351_ TSPTL 1356_ MPRMR 1361_ SHSFY 1366_ SVNMK 1371_ DKGGI 1376_ EKLES 1381_ IFKER 1386_ SLSLH 1391_ RATSS 1396_ HSVAK 1401_ EPKAP 1406_ AAPAN 1411_ TLAIV 1416_ PDSRR 1421_ PSSCI 1426_ DIYVS 1431_ AMDEL 1436_ HCDID 1441_ PLDNS 1446_ VNILG 1451_ LGEPS 1456_ FSTPV 1461_ PSTAP 1466_ SSSAY 1471_ ATLAP 1476_ TDRPP 1481_ SRSID 1486_ FEDIT 1491_ SMDTR 1496_ SFSSD 1501_ YTHLP 1506_ ECQNP 1511_ WDSEP 1516_ PMYHT 1521_ IERSK 1526_ SSRYL 1531_ ATTPF 1536_ LLEEA 1541_ PIVKS 1546_ HSFMF 1551_ SPSRS 1556_ YYANF 1561_ GVPVK 1566_ TAEYT 1571_ SITDC 1576_ IDTRC 1581_ VNAPQ 1586_ AIADR 1591_ AAFPG 1596_ GLGDK 1601_ VEDLT 1606_ CCHPE 1611_ REAEL 1616_ SHPSS 1621_ DSEEN 1626_ EAKGR 1631_ RATIA 1636_ ISSQE 1641_ GDNSE 1646_ RTLSN 1651_ NITVP 1656_ KIERA 1661_ NSYSA 1666_ EEPSA 1671_ PYAHT 1676_ RKSFS 1681_ ISDKL 1686_ DRQRN 1691_ TASLR 1696_ NPFQR 1701_ SKSSK 1706_ PEGRG 1711_ DSLSM 1716_ RRLSR 1721_ TSAFQ 1726_SFESK
1: Constitutively active, non-selective divalent cation-conducting channel that is permeable to Ca(2+), Mn(2+), and Mg(2+), with a high permeability for Ca(2+). However, can be enhanced by increasing temperature and by ligands, including the endogenous neurosteroid pregnenolone sulfate and sphingosine-1 and suppressed by intracellular Mg(2+) (PubMed:12672799, PubMed:12672827, PubMed:32343227). Implicated in a variety of cellular processes, including insulin/peptide secretion, vascular constriction and dilation, noxious heat sensing, inflammatory and spontaneous pain sensitivity. In neurons of the dorsal root ganglia, functions as thermosensitive channel for the detection of noxious heat and spontaneous pain. Suggested to function as an ionotropic steroid receptor in beta-cell, indeed pregnenolone sulfate leads to Ca(2+) influx and enhanced insulin secretion. Mediates Zn(2+) uptake into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion (By similarity). Forms heteromultimeric ion channels with TRPM1 which are permeable for Ca(2+) and Zn(2+) ions (PubMed:21278253). Exists as multiple splice variants which differ significantly in their biophysical properties (By similarity)