Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase)
1_MGTQD 6_ PGNMG 11_ TGVPA 16_ SEQIS 21_ CAKED 26_ PQVYC 31_ PEETG 36_ GTKDV 41_ QVTDC 46_ KSPED 51_ SRPPK 56_ ETDCC 61_ NPEDS 66_ GQLMV 71_ SYEGK 76_ AMGYQ 81_ VPPFG 86_ WRICL 91_ AHEFT 96_ EKRKP 101_ FQANN 106_ VSLSN 111_ MIKHI 116_ GMGLR 121_ YLQWW 126_ YRKTH 131_ VEKKT 136_ PFIDM 141_ INSVP 146_ LRQIY 151_ GCPLG 156_ GIGGG 161_ TITRG 166_ WRGQF 171_ CRWQL 176_ NPGMY 181_ QHRTV 186_ IADQF 191_ TVCLR 196_ REGQT 201_ VYQQV 206_ LSLER 211_ PSVLR 216_ SWNWG 221_ LCGYF 226_ AFYHA 231_ LYPRA 236_ WTVYQ 241_ LPGQN 246_ VTLTC 251_ RQITP 256_ ILPHD 261_ YQDSS 266_ LPVGV 271_ FVWDV 276_ ENEGD 281_ EALDV 286_ SIMFS 291_ MRNGL 296_ GGGDD 301_ APGGL 306_ WNEPF 311_ CLERS 316_ GETVR 321_ GLLLH 326_ HPTLP 331_ NPYTM 336_ AVAAR 341_ VTAAT 346_ TVTHI 351_ TAFDP 356_ DSTGQ 361_ QVWQD 366_ LLQDG 371_ QLDSP 376_ TGQST 381_ PTQKG 386_ VGIAG 391_ AVCVS 396_ SKLRP 401_ RGQCR 406_ LEFSL 411_ AWDMP 416_ RIMFG 421_ AKGQV 426_ HYRRY 431_ TRFFG 436_ QDGDA 441_ APALS 446_ HYALC 451_ RYAEW 456_ EERIS 461_ AWQSP 466_ VLDDR 471_ SLPAW 476_ YKSAL 481_ FNELY 486_ FLADG 491_ GTVWL 496_ EVLED 501_ SLPEE 506_ LGRNM 511_ CHLRP 516_ TLRDY 521_ GRFGY 526_ LEGQE 531_ YRMYN 536_ TYDVH 541_ FYASF 546_ ALIML 551_ WPKLE 556_ LSLQY 561_ DMALA 566_ TLRED 571_ LTRRR 576_ YLMSG 581_ VMAPV 586_ KRRNV 591_ IPHDI 596_ GDPDD 601_ EPWLR 606_ VNAYL 611_ IHDTA 616_ DWKDL 621_ NLKFV 626_ LQVYR 631_ DYYLT 636_ GDQNF 641_ LKDMW 646_ PVCLA 651_ VMESE 656_ MKFDK 661_ DHDGL 666_ IENGG 671_ YADQT 676_ YDGWV 681_ TTGPS 686_ AYCGG 691_ LWLAA 696_ VAVMV 701_ QMAAL 706_ CGAQD 711_ IQDKF 716_ SSILS 721_ RGQEA 726_ YERLL 731_ WNGRY 736_ YNYDS 741_ SSRPQ 746_ SRSVM 751_ SDQCA 756_ GQWFL 761_ KACGL 766_ GEGDT 771_ EVFPT 776_ QHVVR 781_ ALQTI 786_ FELNV 791_ QAFAG 796_ GAMGA 801_ VNGMQ 806_ PHGVP 811_ DKSSV 816_ QSDEV 821_ WVGVV 826_ YGLAA 831_ TMIQE 836_ GLTWE 841_ GFQTA 846_ EGCYR 851_ TVWER 856_ LGLAF 861_ QTPEA 866_ YCQQR 871_ VFRSL 876_ AYMRP 881_ LSIWA 886_ MQLAL 891_ QQQQH 896_ KKASW 901_ PKVKQ 906_ GTGLR 911_ TGPMF 916_ GPKEA 921_MANLS
1: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (PubMed:17105727, PubMed:30308956, PubMed:32144204). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties (PubMed:32144204). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine) (Probable). May play a role in the metabolism of bile acids (PubMed:11489889, PubMed:17080196, PubMed:9111029). Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:11489889, PubMed:17080196, PubMed:9111029). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers (PubMed:32144204)