Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)
1_MKSSV 6_ AQIKP 11_ SSGHD 16_ RRENL 21_ NSYQR 26_ NSSPE 31_ DRYEE 36_ QERSP 41_ RDRDY 46_ FDYSR 51_ SDYEH 56_ SRRGR 61_ SYDSS 66_ MESRN 71_ RDREK 76_ RRERE 81_ RDTDR 86_ KRSRK 91_ SPSPG 96_ RRNPE 101_ TSVTQ 106_ SSSAQ 111_ DEPAT 116_ KKKKD 121_ ELDPL 126_ LTRTG 131_ GAYIP 136_ PAKLR 141_ MMQEQ 146_ ITDKN 151_ SLAYQ 156_ RMSWE 161_ ALKKS 166_ INGLI 171_ NKVNI 176_ SNISI 181_ IIQEL 186_ LQENI 191_ VRGRG 196_ LLSRS 201_ VLQAQ 206_ SASPI 211_ FTHVY 216_ AALVA 221_ IINSK 226_ FPQIG 231_ ELILK 236_ RLILN 241_ FRKGY 246_ RRNDK 251_ QLCLT 256_ ASKFV 261_ AHLIN 266_ QNVAH 271_ EVLCL 276_ EMLTL 281_ LLERP 286_ TDDSV 291_ EVAIG 296_ FLKEC 301_ GLKLT 306_ QVSPR 311_ GINAI 316_ FERLR 321_ NILHE 326_ SEIDK 331_ RVQYM 336_ IEVMF 341_ AVRKD 346_ GFKDH 351_ PIILE 356_ GLDLV 361_ EEDDQ 366_ FTHML 371_ PLEDD 376_ YNPED 381_ VLNVF 386_ KMDPN 391_ FMENE 396_ EKYKA 401_ IKKEI 406_ LDEGD 411_ TDSNT 416_ DQDAG 421_ SSEED 426_ EEEEE 431_ EEGEE 436_ DEEGQ 441_ KVTIH 446_ DKTEI 451_ NLVSF 456_ RRTIY 461_ LAIQS 466_ SLDFE 471_ ECAHK 476_ LLKME 481_ FPESQ 486_ TKELC 491_ NMILD 496_ CCAQQ 501_ RTYEK 506_ FFGLL 511_ AGRFC 516_ MLKKE 521_ YMESF 526_ EGIFK 531_ EQYDT 536_ IHRLE 541_ TNKLR 546_ NVAKM 551_ FAHLL 556_ YTDSL 561_ PWSVL 566_ ECIKL 571_ SEETT 576_ TSSSR 581_ IFVKI 586_ FFQEL 591_ CEYMG 596_ LPKLN 601_ ARLKD 606_ ETLQP 611_ FFEGL 616_ LPRDN 621_ PRNTR 626_ FAINF 631_ FTSIG 636_ LGGLT 641_ DELRE 646_ HLKNT 651_ PKVIV 656_ AQKPD 661_ VEQNK 666_ SSPSS 671_ SSSAS 676_ SSSES 681_ DSSDS 686_ DSDSS 691_ DSSSE 696_ SSSEE 701_ SDSSS 706_ ISSHS 711_ SASAN 716_ DVRKK 721_ GHGKT 726_ RSKEV 731_ DKLIR 736_ NQQTN 741_ DRKQK 746_ ERRQE 751_ HGHQE 756_ TRTER 761_ ERRSE 766_ KHRDQ 771_ NSSGS 776_ NWRDP 781_ ITKYT 786_ SDKDV 791_ PSERN 796_ NYSRV 801_ ANDRD 806_ QEMHI 811_ DLENK 816_ HGDPK 821_ KKRGE 826_ RRNSF 831_ SENEK 836_ HTHRI 841_ KDSEN 846_ FRRKD 851_ RSKSK 856_ EMNRK 861_ HSGSR 866_ SDEDR 871_ YQNGA 876_ ERRWE 881_ KSSRY 886_ SEQSR 891_ ESKKN 896_ QDRRR 901_EKSPA
1: Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay