Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4)
1_MIDLS 6_ FLTEE 11_ EQEAI 16_ MKVLQ 21_ RDAAL 26_ KRAEE 31_ ERVRH 36_ LPEKI 41_ KDDQQ 46_ LKNMS 51_ GQWFY 56_ EAKAK 61_ RHRDK 66_ IHGAD 71_ IIRAS 76_ MRKKR 81_ PQIAA 86_ EQSKD 91_ RENGA 96_ KESWV 101_ NNVNK 106_ DAFLP 111_ PELAG 116_ VVEEP 121_ EEDAA 126_ PASPS 131_ SSVVN 136_ PASSV 141_ IDMSQ 146_ ENTRK 151_ PNVSP 156_ EKRKN 161_ PFNSS 166_ KLPEG 171_ HSSQQ 176_ TKNEQ 181_ SKNGR 186_ TGLFQ 191_ TSKED 196_ ELSES 201_ KEKST 206_ VADTS 211_ IQKLE 216_ KSKQT 221_ LPGLS 226_ NGSQI 231_ KAPIP 236_ KARKM 241_ IYKST 246_ DLNKD 251_ DNQSF 256_ PRQRT 261_ DSLKA 266_ RGAPR 271_ GILKR 276_ NSSSS 281_ STDSE 286_ TLRYN 291_ HNFEP 296_ KSKIV 301_ SPGLT 306_ IHERI 311_ SEKEH 316_ SLEDN 321_ SSPNS 326_ LEPLK 331_ HVRFS 336_ AVKDE 341_ LPQSP 346_ GLIHG 351_ REVGE 356_ FSVLE 361_ SDRLK 366_ NGMED 371_ AGDTE 376_ EFQSD 381_ PKPSQ 386_ YRKPS 391_ LFHQS 396_ TSSPY 401_ VSKSE 406_ THQPM 411_ TSGSF 416_ PINGL 421_ HSHSE 426_ VLTAR 431_ PQSME 436_ NSPTI 441_ NEPKD 446_ KSSEL 451_ TRLES 456_ VLPRS 461_ PADEL 466_ SHCVE 471_ PEPSQ 476_ VPGGS 481_ SRDRQ 486_ QGSEE 491_ EPSPV 496_ LKTLE 501_ RSAAR 506_ KMPSK 511_ SLEDI 516_ SSDSS 521_ NQAKV 526_ DNQPE 531_ ELVRS 536_ AEDVS 541_ TVPTQ 546_ PDNPF 551_ SHPDK 556_ LKRMS 561_ KSVPA 566_ FLQDE 571_ SDDRE 576_ TDTAS 581_ ESSYQ 586_ LSRHK 591_ KSPSS 596_ LTNLS 601_ SSSGM 606_ TSLSS 611_ VSGSV 616_ MSVYS 621_ GDFGN 626_ LEVKG 631_ NIQFA 636_ IEYVE 641_ SLKEL 646_ HVFVA 651_ QCKDL 656_ AAADV 661_ KKQRS 666_ DPYVK 671_ AYLLP 676_ DKGKM 681_ GKKKT 686_ LVVKK 691_ TLNPV 696_ YNEIL 701_ RYKIE 706_ KQILK 711_ TQKLN 716_ LSIWH 721_ RDTFK 726_ RNSFL 731_ GEVEL 736_ DLETW 741_ DWDNK 746_ QNKQL 751_ RWYPL 756_ KRKTA 761_ PVALE 766_ AENRG 771_ EMKLA 776_ LQYVP 781_ EPVPG 786_ KKLPT 791_ TGEVH 796_ IWVKE 801_ CLDLP 806_ LLRGS 811_ HLNSF 816_ VKCTI 821_ LPDTS 826_ RKSRQ 831_ KTRAV 836_ GKTTN 841_ PIFNH 846_ TMVYD 851_ GFRPE 856_ DLMEA 861_ CVELT 866_ VWDHY 871_ KLTNQ 876_ FLGGL 881_ RIGFG 886_ TGKSY 891_ GTEVD 896_ WMDST 901_ SEEVA 906_ LWEKM 911_ VNSPN 916_ TWIEA 921_ TLPLR 926_MLLIA
1: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive