E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184)
1_MNPVN 6_ ATALY 11_ ISASR 16_ LVLNY 21_ DPGDP 26_ KAFTE 31_ INRLL 36_ PYFRQ 41_ SLSCC 46_ VCGHL 51_ LQDPI 56_ APTNS 61_ TCQHY 66_ VCKTC 71_ KGKKM 76_ MMKPS 81_ CSWCK 86_ DYEQF 91_ EENKQ 96_ LSILV 101_ NCYKK 106_ LCEYI 111_ TQTTL 116_ ARDII 121_ EAVDC 126_ SSDIL 131_ ALLND 136_ GSLFC 141_ EETEK 146_ PSDSS 151_ FTLCL 156_ THSPL 161_ PSTSE 166_ PTTDP 171_ QASLS 176_ PMSES 181_ TLSIA 186_ IGSSV 191_ INGLP 196_ TYNGL 201_ SIDRF 206_ GINIP 211_ SPEHS 216_ NTIDV 221_ CNTVD 226_ IKTED 231_ LSDSL 236_ PPVCD 241_ TVATD 246_ LCSTG 251_ IDICS 256_ FSEDI 261_ KPGDS 266_ LLLSV 271_ EEVLR 276_ SLETV 281_ SNTEV 286_ CCPNL 291_ QPNLE 296_ ATVSN 301_ GPFLQ 306_ LSSQS 311_ LSHNV 316_ FMSTS 321_ PALHG 326_ LSCTA 331_ ATPKI 336_ AKLNR 341_ KRSRS 346_ ESDSE 351_ KVQPL 356_ PISTI 361_ IRGPT 366_ LGASA 371_ PVTVK 376_ RESKI 381_ SLQPI 386_ ATVPN 391_ GGTTP 396_ KISKT 401_ VLLST 406_ KSMKK 411_ SHEHG 416_ SKKSH 421_ SKTKP 426_ GILKK 431_ DKAVK 436_ EKIPS 441_ HHFMP 446_ GSPTK 451_ TVYKK 456_ PQEKK 461_ GCKCG 466_ RATQN 471_ PSVLT 476_ CRGQR 481_ CPCYS 486_ NRKAC 491_ LDCIC 496_ RGCQN 501_ SYMAN 506_ GEKKL 511_ EAFAV 516_ PEKAL 521_ EQTRL 526_ TLGIN 531_ VTSIA 536_ VRNAS 541_ TSTSV 546_ INVTG 551_ SPVTT 556_ FLAAS 561_ THDDK 566_ SLDEA 571_IDMRF
1: Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). MSL2 plays a key role in gene dosage by ensuring biallelic expression of a subset of dosage-sensitive genes, including many haploinsufficient genes (By similarity). Acts by promoting promoter-enhancer contacts, thereby preventing DNA methylation of one allele and creating a methylation-free environment for methylation-sensitive transcription factors such as SP1, KANSL1 and KANSL3 (By similarity). Also acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A (PubMed:21726816, PubMed:30930284). This activity is greatly enhanced by heterodimerization with MSL1 (PubMed:21726816, PubMed:30930284). H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). Also involved in the DNA damage response by mediating ubiquitination of TP53/p53 and TP53BP1 (PubMed:19033443, PubMed:23874665)