Progressive ankylosis protein homolog (ANK)
1_MVKFP 6_ ALTHY 11_ WPLIR 16_ FLVPL 21_ GITNI 26_ AIDFG 31_ EQALN 36_ RGIAA 41_ VKEDA 46_ VEMLA 51_ SYGLA 56_ YSLMK 61_ FFTGP 66_ MSDFK 71_ NVGLV 76_ FVNSK 81_ RDRTK 86_ AVLCM 91_ VVAGA 96_ IAAVF 101_ HTLIA 106_ YSDLG 111_ YYIIN 116_ KLHHV 121_ DESVG 126_ SKTRR 131_ AFLYL 136_ AAFPF 141_ MDAMA 146_ WTHAG 151_ ILLKH 156_ KYSFL 161_ VGCAS 166_ ISDVI 171_ AQVVF 176_ VAILL 181_ HSHLE 186_ CREPL 191_ LIPIL 196_ SLYMG 201_ ALVRC 206_ TTLCL 211_ GYYKN 216_ IHDII 221_ PDRSG 226_ PELGG 231_ DATIR 236_ KMLSF 241_ WWPLA 246_ LILAT 251_ QRISR 256_ PIVNL 261_ FVSRD 266_ LGGSS 271_ AATEA 276_ VAILT 281_ ATYPV 286_ GHMPY 291_ GWLTE 296_ IRAVY 301_ PAFDK 306_ NNPSN 311_ KLVST 316_ SNTVT 321_ AAHIK 326_ KFTFV 331_ CMALS 336_ LTLCF 341_ VMFWT 346_ PNVSE 351_ KILID 356_ IIGVD 361_ FAFAE 366_ LCVVP 371_ LRIFS 376_ FFPVP 381_ VTVRA 386_ HLTGW 391_ LMTLK 396_ KTFVL 401_ APSSV 406_ LRIIV 411_ LIASL 416_ VVLPY 421_ LGVHG 426_ ATLGV 431_ GSLLA 436_ GFVGE 441_ STMVA 446_ IAACY 451_ VYRKQ 456_ KKKME 461_ NESAT 466_ EGEDS 471_ AMTDM 476_ PPTEE 481_ VTDIV 486_EMREE
1: Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1 (PubMed:20943778, PubMed:32639996, PubMed:35147247). Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength (PubMed:32639996). The transport mechanism remains to be elucidated (Probable)