Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)
1_MEALG 6_ PGPPA 11_ SLFQP 16_ PRRPG 21_ LGTVG 26_ KPIRL 31_ LANHF 36_ QVQIP 41_ KIDVY 46_ HYDVD 51_ IKPEK 56_ RPRRV 61_ NREVV 66_ DTMVR 71_ HFKMQ 76_ IFGDR 81_ QPGYD 86_ GKRNM 91_ YTAHP 96_ LPIGR 101_ DRVDM 106_ EVTLP 111_ GEGKD 116_ QTFKV 121_ SVQWV 126_ SVVSL 131_ QLLLE 136_ ALAGH 141_ LNEVP 146_ DDSVQ 151_ ALDVI 156_ TRHLP 161_ SMRYT 166_ PVGRS 171_ FFSPP 176_ EGYYH 181_ PLGGG 186_ REVWF 191_ GFHQS 196_ VRPAM 201_ WNMML 206_ NIDVS 211_ ATAFY 216_ RAQPI 221_ IEFMC 226_ EVLDI 231_ QNINE 236_ QTKPL 241_ TDSQR 246_ VKFTK 251_ EIRGL 256_ KVEVT 261_ HCGQM 266_ KRKYR 271_ VCNVT 276_ RRPAS 281_ HQTFP 286_ LQLEN 291_ GQAME 296_ CTVAQ 301_ YFKQK 306_ YSLQL 311_ KYPHL 316_ PCLQV 321_ GQEQK 326_ HTYLP 331_ LEVCN 336_ IVAGQ 341_ RCIKK 346_ LTDNQ 351_ TSTMI 356_ KATAR 361_ SAPDR 366_ QEEIS 371_ RLVKS 376_ NSMVG 381_ GPDPY 386_ LKEFG 391_ IVVHN 396_ EMTEL 401_ TGRVL 406_ PAPML 411_ QYGGR 416_ NKTVA 421_ TPNQG 426_ VWDMR 431_ GKQFY 436_ AGIEI 441_ KVWAV 446_ ACFAP 451_ QKQCR 456_ EDLLK 461_ SFTDQ 466_ LRKIS 471_ KDAGM 476_ PIQGQ 481_ PCFCK 486_ YAQGA 491_ DSVEP 496_ MFKHL 501_ KMTYV 506_ GLQLI 511_ VVILP 516_ GKTPV 521_ YAEVK 526_ RVGDT 531_ LLGMA 536_ TQCVQ 541_ VKNVV 546_ KTSPQ 551_ TLSNL 556_ CLKIN 561_ AKLGG 566_ INNVL 571_ VPHQR 576_ PSVFQ 581_ QPVIF 586_ LGADV 591_ THPPA 596_ GDGKK 601_ PSIAA 606_ VVGSM 611_ DGHPS 616_ RYCAT 621_ VRVQT 626_ SRQEI 631_ SQELL 636_ YSQEV 641_ IQDLT 646_ NMVRE 651_ LLIQF 656_ YKSTR 661_ FKPTR 666_ IIYYR 671_ GGVSE 676_ GQMKQ 681_ VAWPE 686_ LIAIR 691_ KACIS 696_ LEEDY 701_ RPGIT 706_ YIVVQ 711_ KRHHT 716_ RLFCA 721_ DKTER 726_ VGKSG 731_ NVPAG 736_ TTVDS 741_ TITHP 746_ SEFDF 751_ YLCSH 756_ AGIQG 761_ TSRPS 766_ HYQVL 771_ WDDNC 776_ FTADE 781_ LQLLT 786_ YQLCH 791_ TYVRC 796_ TRSVS 801_ IPAPA 806_ YYARL 811_ VAFRA 816_ RYHLV 821_ DKDHD 826_ SAEGS 831_ HVSGQ 836_ SNGRD 841_ PQALA 846_ KAVQI 851_ HHDTQ 856_HTMYF
1: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV)