Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
1_MADPI 6_ MDLFD 11_ DPNLF 16_ GLDSL 21_ TDDSF 26_ NQVTQ 31_ DPIEE 36_ ALGLP 41_ SSLDS 46_ LDQMN 51_ QDGGG 56_ GDVGN 61_ SSASE 66_ LVPPP 71_ EETAP 76_ TELSK 81_ ESTAP 86_ APESI 91_ TLHDY 96_ TTQPA 101_ SQEQP 106_ AQPVL 111_ QTSTP 116_ TSGLL 121_ QVSKS 126_ QEILS 131_ QGNPF 136_ MGVSA 141_ TAVSS 146_ SSAGG 151_ QPPQS 156_ APKIV 161_ ILKAP 166_ PSSSV 171_ TGAHV 176_ AQIQA 181_ QGITS 186_ TAQPL 191_ VAGTA 196_ NGGKV 201_ TFTKV 206_ LTGTP 211_ LRPGV 216_ SIVSG 221_ NTVLA 226_ AKVPG 231_ NQAAV 236_ QRIVQ 241_ PSRPV 246_ KQLVL 251_ QPVKG 256_ SAPAG 261_ NPGAT 266_ GPPLK 271_ PAVTL 276_ TSTPT 281_ QGESK 286_ RITLV 291_ LQQPQ 296_ SGGPQ 301_ GHRHV 306_ VLGSL 311_ PGKIV 316_ LQGNQ 321_ LAALT 326_ QAKNA 331_ QGQPA 336_ KVVTI 341_ QLQVQ 346_ QPQQK 351_ IQIVP 356_ QPPSS 361_ QPQPQ 366_ QPPST 371_ QPVTL 376_ SSVQQ 381_ AQIMG 386_ PGQSP 391_ GQRLS 396_ VPVKV 401_ VLQPQ 406_ AGSSQ 411_ GASSG 416_ LSVVK 421_ VLSAS 426_ EVAAL 431_ SSPAS 436_ SAPHS 441_ GGKTG 446_ MEENR 451_ RLEHQ 456_ KKQEK 461_ ANRIV 466_ AEAIA 471_ RARAR 476_ GEQNI 481_ PRVLN 486_ EDELP 491_ SVRPE 496_ EEGEK 501_ KRRKK 506_ SAGER 511_ LKEEK 516_ PKKSK 521_ TSGAS 526_ KTKGK 531_ SKLNT 536_ ITPVV 541_ GKKRK 546_ RNTSS 551_ DNSDV 556_ EVMPA 561_ QSPRE 566_ DEESS 571_ IQKRR 576_ SNRQV 581_ KRKKY 586_ TEDLD 591_ IKITD 596_ DEEEE 601_ EVDVT 606_ GPIKP 611_ EPILP 616_ EPVQE 621_ PDGET 626_ LPSMQ 631_ FFVEN 636_ PSEED 641_ AAIVD 646_ KVLSM 651_ RIVKK 656_ ELPSG 661_ QYTEA 666_ EEFFV 671_ KYKNY 676_ SYLHC 681_ EWATI 686_ SQLEK 691_ DKRIH 696_ QKLKR 701_ FKTKM 706_ AQMRH 711_ FFHED 716_ EEPFN 721_ PDYVE 726_ VDRIL 731_ DESHS 736_ IDKDN 741_ GEPVI 746_ YYLVK 751_ WCSLP 756_ YEDST 761_ WELKE 766_ DVDEG 771_ KIREF 776_ KRIQS 781_ RHPEL 786_ KRVNR 791_ PQASA 796_ WKKLE 801_ LSHEY 806_ KNRNQ 811_ LREYQ 816_ LEGVN 821_ WLLFN 826_ WYNRQ 831_ NCILA 836_ DEMGL 841_ GKTIQ 846_ SIAFL 851_ QEVYN 856_ VGIHG 861_ PFLVI 866_ APLST 871_ ITNWE 876_ REFNT 881_ WTEMN 886_ TIVYH 891_ GSLAS 896_ RQMIQ 901_ QYEMY 906_ CKDSR 911_ GRLIP 916_ GAYKF 921_ DALIT 926_ TFEMI 931_ LSDCP 936_ ELREI 941_ EWRCV 946_ IIDEA 951_ HRLKN 956_ RNCKL 961_ LDSLK 966_ HMDLE 971_ HKVLL 976_ TGTPL 981_ QNTVE 986_ ELFSL 991_ LHFLE 996_ PSQFP 1001_ SESEF 1006_ LKDFG 1011_ DLKTE 1016_ EQVQK 1021_ LQAIL 1026_ KPMML 1031_ RRLKE 1036_ DVEKN 1041_ LAPKQ 1046_ ETIIE 1051_ VELTN 1056_ IQKKY 1061_ YRAIL 1066_ EKNFS 1071_ FLSKG 1076_ AGHTN 1081_ MPNLL 1086_ NTMME 1091_ LRKCC 1096_ NHPYL 1101_ INGAE 1106_ EKILT 1111_ EFREA 1116_ CHIIP 1121_ HDFHL 1126_ QAMVR 1131_ SAGKL 1136_ VLIDK 1141_ LLPKL 1146_ KAGGH 1151_ KVLIF 1156_ SQMVR 1161_ CLDIL 1166_ EDYLI 1171_ QRRYL 1176_ YERID 1181_ GRVRG 1186_ NLRQA 1191_ AIDRF 1196_ SKPDS 1201_ DRFVF 1206_ LLCTR 1211_ AGGLG 1216_ INLTA 1221_ ADTCI 1226_ IFDSD 1231_ WNPQN 1236_ DLQAQ 1241_ ARCHR 1246_ IGQSK 1251_ AVKVY 1256_ RLITR 1261_ NSYER 1266_ EMFDK 1271_ ASLKL 1276_ GLDKA 1281_ VLQSM 1286_ SGRDG 1291_ NITGI 1296_ QQFSK 1301_ KEIED 1306_ LLRKG 1311_ AYAAI 1316_ MEEDD 1321_ EGSKF 1326_ CEEDI 1331_ DQILL 1336_ RRTTT 1341_ ITIES 1346_ EGKGS 1351_ TFAKA 1356_ SFVAS 1361_ ENRTD 1366_ ISLDD 1371_ PNFWQ 1376_ KWAKK 1381_ ADLDM 1386_ DLLNS 1391_ KNNLV 1396_ IDTPR 1401_ VRKQT 1406_ RHFST 1411_ LKDDD 1416_ LVEFS 1421_ DLESE 1426_ DDERP 1431_ RSRRH 1436_ DRHHA 1441_ YGRTD 1446_ CFRVE 1451_ KHLLV 1456_ YGWGR 1461_ WRDIL 1466_ SHGRF 1471_ KRRMT 1476_ ERDVE 1481_ TICRA 1486_ ILVYC 1491_ LLHYR 1496_ GDENI 1501_ KGFIW 1506_ DLISP 1511_ AENGK 1516_ TKELQ 1521_ NHSGL 1526_ SIPVP 1531_ RGRKG 1536_ KKVKS 1541_ QSTFD 1546_ IHKAD 1551_ WIRKY 1556_ NPDTL 1561_ FQDES 1566_ YKKHL 1571_ KHQCN 1576_ KVLLR 1581_ VRMLY 1586_ YLRQE 1591_ VIGDQ 1596_ AEKVL 1601_ GGAIA 1606_ SEIDI 1611_ WFPVV 1616_ DQLEV 1621_ PTTWW 1626_ DSEAD 1631_ KSLLI 1636_ GVFKH 1641_ GYEKY 1646_ NTMRA 1651_ DPALC 1656_ FLEKA 1661_ GRPDD 1666_ KAIAA 1671_ EHRVL 1676_ DNFSD 1681_ IVEGV 1686_ DFDKD 1691_ CEDPE 1696_ YKPLQ 1701_ GPPKD 1706_ QDDEG 1711_ DPLMM 1716_ MDEEI 1721_ SVIDG 1726_ DEAQV 1731_ TQQPG 1736_ HLFWP 1741_ PGSAL 1746_ TARLR 1751_ RLVTA 1756_ YQRSY 1761_ KREQM 1766_ KIEAA 1771_ ERGDR 1776_ RRRRC 1781_ EAAFK 1786_ LKEIA 1791_ RREKQ 1796_ QRWTR 1801_ REQTD 1806_ FYRVV 1811_ STFGV 1816_ EYDPD 1821_ TMQFH 1826_ WDRFR 1831_ TFARL 1836_ DKKTD 1841_ ESLTK 1846_ YFHGF 1851_ VAMCR 1856_ QVCRL 1861_ PPAAG 1866_ DEPPD 1871_ PNLFI 1876_ EPITE 1881_ ERASR 1886_ TLYRI 1891_ ELLRR 1896_ LREQV 1901_ LCHPL 1906_ LEDRL 1911_ ALCQP 1916_ PGPEL 1921_ PKWWE 1926_ PVRHD 1931_ GELLR 1936_ GAARH 1941_ GVSQT 1946_ DCNIM 1951_ QDPDF 1956_ SFLAA 1961_ RMNYM 1966_ QNHQA 1971_ GAPAP 1976_ SLSRC 1981_ STPLL 1986_ HQQYT 1991_ SRTAS 1996_ PLPLR 2001_ PDAPV 2006_ EKSPE 2011_ ETATQ 2016_ VPSLE 2021_ SLTLK 2026_ LEHEV 2031_ VARSR 2036_ PTPQD 2041_ YEMRV 2046_ SPSDT 2051_ TPLVS 2056_ RSVPP 2061_ VKLED 2066_ EDDSD 2071_ SELDL 2076_ SKLSP 2081_ SSSSS 2086_ SSSSS 2091_ SSSST 2096_ DESED 2101_ EKEEK 2106_ LTDQS 2111_ RSKLY 2116_ DEESL 2121_ LSLTM 2126_ SQDGF 2131_ PNEDG 2136_ EQMTP 2141_ ELLLL 2146_ QERQR 2151_ ASEWP 2156_ KDRVL 2161_ INRID 2166_ LVCQA 2171_ VLSGK 2176_ WPSSR 2181_ RSQEM 2186_ VTGGI 2191_ LGPGN 2196_ HLLDS 2201_ PSLTP 2206_ GEYGD 2211_ SPVPT 2216_ PRSSS 2221_ AASMA 2226_ EEEAS 2231_ AVSTA 2236_ AAQFT 2241_ KLRRG 2246_ MDEKE 2251_ FTVQI 2256_ KDEEG 2261_ LKLTF 2266_ QKHKL 2271_ MANGV 2276_ MGDGH 2281_ PLFHK 2286_ KKGNR 2291_ KKLVE 2296_ LEVEC 2301_ MEEPN 2306_ HLDVD 2311_ LETRI 2316_ PVINK 2321_ VDGTL 2326_ LVGED 2331_ APRRA 2336_ ELEMW 2341_ LQGHP 2346_ EFAVD 2351_ PRFLA 2356_ YMEDR 2361_ RKQKW 2366_ QRCKK 2371_ NNKAE 2376_ LNCLG 2381_ MEPVQ 2386_ TANSR 2391_ NGKKG 2396_ HHTET 2401_ VFNRV 2406_ LPGPI 2411_ APESS 2416_ KKRAR 2421_ RMRPD 2426_ LSKMM 2431_ ALMQG 2436_ GSTGS 2441_ LSLHN 2446_ TFQHS 2451_ SSGLQ 2456_ SVSSL 2461_ GHSSA 2466_ TSASL 2471_ PFMPF 2476_ VMGGA 2481_ PSSPH 2486_ VDSST 2491_ MLHHH 2496_ HHHPH 2501_ PHHHH 2506_ HHHPG 2511_ LRAPG 2516_ YPSSP 2521_ VTTAS 2526_ GTTLR 2531_ LPPLQ 2536_ PEEDD 2541_ DEDEE 2546_ DDDDL 2551_ SQGYD 2556_ SSERD 2561_ FSLID 2566_ DPMMP 2571_ ANSDS 2576_SEDAD
1: ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL