Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)
1_MDESA 6_ LTLGT 11_ IDVSY 16_ LPHSS 21_ EYSVG 26_ RCKHT 31_ SEEWG 36_ ECGFR 41_ PTIFR 46_ SATLK 51_ WKESL 56_ MSRKR 61_ PFVGR 66_ CCYSC 71_ TPQSW 76_ DKFFN 81_ PSIPS 86_ LGLRN 91_ VIYIN 96_ ETHTR 101_ HRGWL 106_ ARRLS 111_ YVLFI 116_ QERDV 121_ HKGMF 126_ ATNVT 131_ ENVLN 136_ SSRVQ 141_ EAIAE 146_ VAAEL 151_ NPDGS 156_ AQQQS 161_ KAVNK 166_ VKKKA 171_ KRILQ 176_ EMVAT 181_ VSPAM 186_ IRLTG 191_ WVLLK 196_ LFNSF 201_ FWNIQ 206_ IHKGQ 211_ LEMVK 216_ AATET 221_ NLPLL 226_ FLPVH 231_ RSHID 236_ YLLLT 241_ FILFC 246_ HNIKA 251_ PYIAS 256_ GNNLN 261_ IPIFS 266_ TLIHK 271_ LGGFF 276_ IRRRL 281_ DETPD 286_ GRKDV 291_ LYRAL 296_ LHGHI 301_ VELLR 306_ QQQFL 311_ EIFLE 316_ GTRSR 321_ SGKTS 326_ CARAG 331_ LLSVV 336_ VDTLS 341_ TNVIP 346_ DILII 351_ PVGIS 356_ YDRII 361_ EGHYN 366_ GEQLG 371_ KPKKN 376_ ESLWS 381_ VARGV 386_ IRMLR 391_ KNYGC 396_ VRVDF 401_ AQPFS 406_ LKEYL 411_ ESQSQ 416_ KPVSA 421_ LLSLE 426_ QALLP 431_ AILPS 436_ RPSDA 441_ ADEGR 446_ DTSIN 451_ ESRNA 456_ TDESL 461_ RRRLI 466_ ANLAE 471_ HILFT 476_ ASKSC 481_ AIMST 486_ HIVAC 491_ LLLYR 496_ HRQGI 501_ DLSTL 506_ VEDFF 511_ VMKEE 516_ VLARD 521_ FDLGF 526_ SGNSE 531_ DVVMH 536_ AIQLL 541_ GNCVT 546_ ITHTS 551_ RNDEF 556_ FITPS 561_ TTVPS 566_ VFELN 571_ FYSNG 576_ VLHVF 581_ IMEAI 586_ IACSL 591_ YAVLN 596_ KRGLG 601_ GPTST 606_ PPNLI 611_ SQEQL 616_ VRKAA 621_ SLCYL 626_ LSNEG 631_ TISLP 636_ CQTFY 641_ QVCHE 646_ TVGKF 651_ IQYGI 656_ LTVAE 661_ HDDQE 666_ DISPS 671_ LAEQQ 676_ WDKKL 681_ PEPLS 686_ WRSDE 691_ EDEDS 696_ DFGEE 701_ QRDCY 706_ LKVSQ 711_ SKEHQ 716_ QFITF 721_ LQRLL 726_ GPLLE 731_ AYSSA 736_ AIFVH 741_ NFSGP 746_ VPEPE 751_ YLQKL 756_ HKYLI 761_ TRTER 766_ NVAVY 771_ AESAT 776_ YCLVK 781_ NAVKM 786_ FKDIG 791_ VFKET 796_ KQKRV 801_ SVLEL 806_ SSTFL 811_ PQCNR 816_ QKLLE 821_YILSF
1: Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids (PubMed:18238778, PubMed:19075029, PubMed:36522428). Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid (PubMed:18238778). Has a narrow hydrophobic binding cleft that selects for a linear acyl chain (PubMed:36522428). Catalytic activity is higher for substrates with a 16-carbon acyl chain (PubMed:36522428)