E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)
1_MAETS 6_ LLEAG 11_ ASAAS 16_ TAAAL 21_ ENLQV 26_ EASCS 31_ VCLEY 36_ LKEPV 41_ IIECG 46_ HNFCK 51_ ACITR 56_ WWEDL 61_ ERDFP 66_ CPVCR 71_ KTSRY 76_ RSLRP 81_ NRQLG 86_ SMVEI 91_ AKQLQ 96_ AVKRK 101_ IRDES 106_ LCPQH 111_ HEALS 116_ LFCYE 121_ DQEAV 126_ CLICA 131_ ISHTH 136_ RAHTV 141_ VPLDD 146_ ATQEY 151_ KEKLQ 156_ KCLEP 161_ LEQKL 166_ QEITR 171_ CKSSE 176_ EKKPG 181_ ELKRL 186_ VESRR 191_ QQILR 196_ EFEEL 201_ HRRLD 206_ EEQQV 211_ LLSRL 216_ EEEEQ 221_ DILQR 226_ LRENA 231_ AHLGD 236_ KRRDL 241_ AHLAA 246_ EVEGK 251_ CLQSG 256_ FEMLK 261_ DVKST 266_ LEKNI 271_ PRKFG 276_ GSLST 281_ ICPRD 286_ HKALL 291_ GLVKE 296_ INRCE 301_ KVKTM 306_ EVTSV 311_ SIELE 316_ KNFSN 321_ FPRQY 326_ FALRK 331_ ILKQL 336_ IADVT 341_ LDPET 346_ AHPNL 351_ VLSED 356_ RKSVK 361_ FVETR 366_ LRDLP 371_ DTPRR 376_ FTFYP 381_ CVLAT 386_ EGFTS 391_ GRHYW 396_ EVEVG 401_ DKTHW 406_ AVGVC 411_ RDSVS 416_ RKGEL 421_ TPLPE 426_ TGYWR 431_ VRLWN 436_ GDKYA 441_ ATTTP 446_ FTPLH 451_ IKVKP 456_ KRVGI 461_ FLDYE 466_ AGTLS 471_ FYNVT 476_ DRSHI 481_ YTFTD 486_ TFTEK 491_ LWPLF 496_ YPGIR 501_ AGRKN 506_ AAPLT 511_IRPPT
1: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251)
2: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554)