Post-GPI attachment to proteins factor 6 (EC 3.1.1.4) (GPI processing phospholipase A2) (GPI-PLA2) (Protein M83) (Transmembrane protein 6) (Transmembrane protein 8) (Transmembrane protein 8A)
1_MGRAG 6_ TGTGG 11_ EAVAA 16_ VVAGP 21_ LLLLL 26_ LARPP 31_ PASAG 36_ YSGKS 41_ EVGLV 46_ SEHFS 51_ QAPQR 56_ LSFYS 61_ WYGSA 66_ RLFRF 71_ RVPPD 76_ AVLLR 81_ WLLQV 86_ SRESG 91_ AACTD 96_ AEITV 101_ HFRSG 106_ APPVI 111_ NPLGT 116_ SFPDD 121_ TAVQP 126_ SFQVG 131_ VPLST 136_ TPRSN 141_ ASVNV 146_ SHPAP 151_ GDWFV 156_ AAHLP 161_ PSSQK 166_ IELKG 171_ LAPTC 176_ AYVFQ 181_ PELLV 186_ TRVVE 191_ ISIME 196_ PDVPL 201_ PQTLL 206_ SHPSY 211_ LKVFV 216_ PDYTR 221_ ELLLE 226_ LRDCV 231_ SNGSL 236_ GCPVR 241_ LTVGP 246_ VTLPS 251_ NFQKV 256_ LTCTG 261_ APWPC 266_ RLLLP 271_ SPPWD 276_ RWLQV 281_ TAESL 286_ VGPLG 291_ TVAFS 296_ AVAAL 301_ TACRP 306_ RSVTI 311_ QPLLQ 316_ SSQNQ 321_ SFNAS 326_ SGLLS 331_ PSPDH 336_ QDLGR 341_ SGRVD 346_ RSPFC 351_ LTNYP 356_ VTRED 361_ MDVVS 366_ VHFQP 371_ LDRVS 376_ VRVCS 381_ DTPSV 386_ MRLRL 391_ NTGMD 396_ SGGSL 401_ TISLR 406_ ANKTE 411_ MRNET 416_ VVVAC 421_ VNAAS 426_ PFLGF 431_ NTSLN 436_ CTTAF 441_ FQGYP 446_ LSLSA 451_ WSRRA 456_ NLIIP 461_ YPETD 466_ NWYLS 471_ LQLMC 476_ PENAE 481_ DCEQA 486_ VVHVE 491_ TTLYL 496_ VPCLN 501_ DCGPY 506_ GQCLL 511_ LRRHS 516_ YLYAS 521_ CSCKA 526_ GWRGW 531_ SCTDN 536_ STAQT 541_ VAQQR 546_ AATLL 551_ LTLSN 556_ LMFLA 561_ PIAVS 566_ VRRFF 571_ LVEAS 576_ VYAYT 581_ MFFST 586_ FYHAC 591_ DQPGE 596_ AVLCI 601_ LSYDT 606_ LQYCD 611_ FLGSG 616_ AAIWV 621_ TILCM 626_ ARLKT 631_ VLKYV 636_ LFLLG 641_ TLVIA 646_ MSLQL 651_ DRRGM 656_ WNMLG 661_ PCLFA 666_ FVIMA 671_ SMWAY 676_ RCGHR 681_ RQCYP 686_ TSWQR 691_ WAFYL 696_ LPGVS 701_ MASVG 706_ IAIYT 711_ SMMTS 716_ DNYYY 721_ THSIW 726_ HILLA 731_ GSAAL 736_ LLPPP 741_ DQPAE 746_ PWACS 751_ QKFPC 756_ HYQIC 761_ KNDRE 766_ELYAV
1: Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401)