Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
1_MSPSP 6_ TALFC 11_ LGLCL 16_ GRVPA 21_ QSGPL 26_ PKPSL 31_ QALPS 36_ SLVPL 41_ EKPVT 46_ LRCQG 51_ PPGVD 56_ LYRLE 61_ KLSSS 66_ RYQDQ 71_ AVLFI 76_ PAMKR 81_ SLAGR 86_ YRCSY 91_ QNGSL 96_ WSLPS 101_ DQLEL 106_ VATGV 111_ FAKPS 116_ LSAQP 121_ GPAVS 126_ SGGDV 131_ TLQCQ 136_ TRYGF 141_ DQFAL 146_ YKEGD 151_ PAPYK 156_ NPERW 161_ YRASF 166_ PIITV 171_ TAAHS 176_ GTYRC 181_ YSFSS 186_ RDPYL 191_ WSAPS 196_ DPLEL 201_ VVTGT 206_ SVTPS 211_ RLPTE 216_ PPSPV 221_ AEFSE 226_ ATAEL 231_ TVSFT 236_ NEVFT 241_ TETSR 246_ SITAS 251_ PKESD 256_ SPAGP 261_ ARQYY 266_ TKGNL 271_ VRICL 276_ GAVIL 281_ IILAG 286_ FLAED 291_ WHSRR 296_ KRLRH 301_ RGRAV 306_ QRPLP 311_ PLPPL 316_ PLTRK 321_ SNGGQ 326_ DGGRQ 331_DVHSR
1: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2