Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)
1_MAASR 6_ LDFGE 11_ VETFL 16_ DRHPE 21_ LFEDY 26_ LMRKG 31_ KQEMV 36_ EKWLQ 41_ RHSQG 46_ QGALG 51_ PRPSL 56_ AGTSS 61_ LAHST 66_ CRGGS 71_ SVGGG 76_ TGPNG 81_ SAHSQ 86_ PLPGG 91_ GDCGG 96_ VPLSP 101_ SWAGG 106_ SRGDG 111_ NLQRR 116_ ASQKE 121_ LRKSF 126_ ARSKA 131_ IHVNR 136_ TYDEQ 141_ VTSRA 146_ QEPLS 151_ SVRRR 156_ ALLRK 161_ ASSLP 166_ PTTAH 171_ ILSAL 176_ LESRV 181_ NLPRY 186_ PPTAI 191_ DYKCH 196_ LKKHN 201_ ERQFF 206_ LELVK 211_ DISND 216_ LDLTS 221_ LSYKI 226_ LIFVC 231_ LMVDA 236_ DRCSL 241_ FLVEG 246_ AAAGK 251_ KTLVS 256_ KFFDV 261_ HAGTP 266_ LLPCS 271_ STENS 276_ NEVQV 281_ PWGKG 286_ IIGYV 291_ GEHGE 296_ TVNIP 301_ DAYQD 306_ RRFND 311_ EIDKL 316_ TGYKT 321_ KSLLC 326_ MPIRS 331_ SDGEI 336_ IGVAQ 341_ AINKI 346_ PEGAP 351_ FTEDD 356_ EKVMQ 361_ MYLPF 366_ CGIAI 371_ SNAQL 376_ FAASR 381_ KEYER 386_ SRALL 391_ EVVND 396_ LFEEQ 401_ TDLEK 406_ IVKKI 411_ MHRAQ 416_ TLLKC 421_ ERCSV 426_ LLLED 431_ IESPV 436_ VKFTK 441_ SFELM 446_ SPKCS 451_ ADAEN 456_ SFKES 461_ MEKSS 466_ YSDWL 471_ INNSI 476_ AELVA 481_ STGLP 486_ VNISD 491_ AYQDP 496_ RFDAE 501_ ADQIS 506_ GFHIR 511_ SVLCV 516_ PIWNS 521_ NHQII 526_ GVAQV 531_ LNRLD 536_ GKPFD 541_ DADQR 546_ LFEAF 551_ VIFCG 556_ LGINN 561_ TIMYD 566_ QVKKS 571_ WAKQS 576_ VALDV 581_ LSYHA 586_ TCSKA 591_ EVDKF 596_ KAANI 601_ PLVSE 606_ LAIDD 611_ IHFDD 616_ FSLDV 621_ DAMIT 626_ AALRM 631_ FMELG 636_ MVQKF 641_ KIDYE 646_ TLCRW 651_ LLTVR 656_ KNYRM 661_ VLYHN 666_ WRHAF 671_ NVCQL 676_ MFAML 681_ TTAGF 686_ QDILT 691_ EVEIL 696_ AVIVG 701_ CLCHD 706_ LDHRG 711_ TNNAF 716_ QAKSG 721_ SALAQ 726_ LYGTS 731_ ATLEH 736_ HHFNH 741_ AVMIL 746_ QSEGH 751_ NIFAN 756_ LSSKE 761_ YSDLM 766_ QLLKQ 771_ SILAT 776_ DLTLY 781_ FERRT 786_ EFFEL 791_ VSKGE 796_ YDWNI 801_ KNHRD 806_ IFRSM 811_ LMTAC 816_ DLGAV 821_ TKPWE 826_ ISRQV 831_ AELVT 836_ SEFFE 841_ QGDRE 846_ RLELK 851_ LTPSA 856_ IFDRN 861_ RKDEL 866_ PRLQL 871_ EWIDS 876_ ICMPL 881_ YQALV 886_ KVNVK 891_ LKPML 896_ DSVAT 901_ NRSKW 906_ EELHQ 911_ KRLLA 916_ STASS 921_ SPASV 926_MVAKE
1: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148)