Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)
1_MSLLS 6_ LPWLG 11_ LRPVA 16_ TSPWL 21_ LLLLV 26_ VGSWL 31_ LARIL 36_ AWTYA 41_ FYNNC 46_ RRLQC 51_ FPQPP 56_ KRNWF 61_ WGHLG 66_ LITPT 71_ EEGLK 76_ NSTQM 81_ SATYS 86_ QGFTV 91_ WLGPI 96_ IPFIV 101_ LCHPD 106_ TIRSI 111_ TNASA 116_ AIAPK 121_ DNLFI 126_ RFLKP 131_ WLGEG 136_ ILLSG 141_ GDKWS 146_ RHRRM 151_ LTPAF 156_ HFNIL 161_ KSYIT 166_ IFNKS 171_ ANIML 176_ DKWQH 181_ LASEG 186_ SSRLD 191_ MFEHI 196_ SLMTL 201_ DSLQK 206_ CIFSF 211_ DSHCQ 216_ ERPSE 221_ YIATI 226_ LELSA 231_ LVEKR 236_ SQHIL 241_ QHMDF 246_ LYYLS 251_ HDGRR 256_ FHRAC 261_ RLVHD 266_ FTDAV 271_ IRERR 276_ RTLPT 281_ QGIDD 286_ FFKDK 291_ AKSKT 296_ LDFID 301_ VLLLS 306_ KDEDG 311_ KALSD 316_ EDIRA 321_ EADTF 326_ MFGGH 331_ DTTAS 336_ GLSWV 341_ LYNLA 346_ RHPEY 351_ QERCR 356_ QEVQE 361_ LLKDR 366_ DPKEI 371_ EWDDL 376_ AQLPF 381_ LTMCV 386_ KESLR 391_ LHPPA 396_ PFISR 401_ CCTQD 406_ IVLPD 411_ GRVIP 416_ KGITC 421_ LIDII 426_ GVHHN 431_ PTVWP 436_ DPEVY 441_ DPFRF 446_ DPENS 451_ KGRSP 456_ LAFIP 461_ FSAGP 466_ RNCIG 471_ QAFAM 476_ AEMKV 481_ VLALM 486_ LLHFR 491_ FLPDH 496_ TEPRR 501_ KLELI 506_ MRAEG 511_ GLWLR 516_VEPLN
1: A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position. Metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonate (PubMed:11162607). Catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acids (PubMed:16112640). Has low omega-hydroxylase activity toward leukotriene B4 and arachidonate (PubMed:11162645). Involved in the metabolism of xenobiotics. Catalyzes the hydroxylation of the antihistamine drug ebastine (PubMed:11162645)