Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3)
1_MPQLG 6_ GGGGG 11_ GGGGS 16_ GGGGG 21_ SSAGA 26_ AGGGD 31_ DLGAN 36_ DELIP 41_ FQDEG 46_ GEEQE 51_ PSSDS 56_ ASAQR 61_ DLDEV 66_ KSSLV 71_ NESEN 76_ QSSSS 81_ DSEAE 86_ RRPQP 91_ VRDTF 96_ QKPRD 101_ YFAEV 106_ RRPQD 111_ SAFFK 116_ GPPYP 121_ GYPFL 126_ MIPDL 131_ SSPYL 136_ SNGPL 141_ SPGGA 146_ RTYLQ 151_ MKWPL 156_ LDVPS 161_ SATVK 166_ DTRSP 171_ SPAHL 176_ SNKVP 181_ VVQHP 186_ HHMHP 191_ LTPLI 196_ TYSND 201_ HFSPG 206_ SPPTH 211_ LSPEI 216_ DPKTG 221_ IPRPP 226_ HPSEL 231_ SPYYP 236_ LSPGA 241_ VGQIP 246_ HPLGW 251_ LVPQQ 256_ GQPMY 261_ SLPPG 266_ GFRHP 271_ YPALA 276_ MNASM 281_ SSLVS 286_ SRFSP 291_ HMVAP 296_ AHPGL 301_ PTSGI 306_ PHPAI 311_ VSPIV 316_ KQEPA 321_ PPSLS 326_ PAVSV 331_ KSPVT 336_ VKKEE 341_ EKKPH 346_ VKKPL 351_ NAFML 356_ YMKEM 361_ RAKVV 366_ AECTL 371_ KESAA 376_ INQIL 381_ GRKWH 386_ NLSRE 391_ EQAKY 396_ YELAR 401_ KERQL 406_ HSQLY 411_ PTWSA 416_ RDNYG 421_ KKKKR 426_ KREKQ 431_ LSQTQ 436_ SQQQV 441_ QEAEG 446_ ALASK 451_ SKKPC 456_ VQYLP 461_ PEKPC 466_ DSPAS 471_ SHGSM 476_ LDSPA 481_ TPSAA 486_ LASPA 491_ APAAT 496_ HSEQA 501_ QPLSL 506_ TTKPE 511_ TRAQL 516_ ALHSA 521_ AFLSA 526_ KAAAS 531_ SSGQM 536_ GSQPP 541_ LLSRP 546_ LPLGS 551_ MPTAL 556_ LASPP 561_ SFPAT 566_ LHAHQ 571_ ALPVL 576_ QAQPL 581_SLVTK
1: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance