Endosialin (Tumor endothelial marker 1) (CD antigen CD248)
1_MLLRL 6_ LLAWA 11_ AAGPT 16_ LGQDP 21_ WAAEP 26_ RAACG 31_ PSSCY 36_ ALFPR 41_ RRTFL 46_ EAWRA 51_ CRELG 56_ GDLAT 61_ PRTPE 66_ EAQRV 71_ DSLVG 76_ AGPAS 81_ RLLWI 86_ GLQRQ 91_ ARQCQ 96_ LQRPL 101_ RGFTW 106_ TTGDQ 111_ DTAFT 116_ NWAQP 121_ ASGGP 126_ CPAQR 131_ CVALE 136_ ASGEH 141_ RWLEG 146_ SCTLA 151_ VDGYL 156_ CQFGF 161_ EGACP 166_ ALQDE 171_ AGQAG 176_ PAVYT 181_ TPFHL 186_ VSTEF 191_ EWLPF 196_ GSVAA 201_ VQCQA 206_ GRGAS 211_ LLCVK 216_ QPEGG 221_ VGWSR 226_ AGPLC 231_ LGTGC 236_ SPDNG 241_ GCEHE 246_ CVEEV 251_ DGHVS 256_ CRCTE 261_ GFRLA 266_ ADGRS 271_ CEDPC 276_ AQAPC 281_ EQQCE 286_ PGGPQ 291_ GYSCH 296_ CRLGF 301_ RPAED 306_ DPHRC 311_ VDTDE 316_ CQIAG 321_ VCQQM 326_ CVNYV 331_ GGFEC 336_ YCSEG 341_ HELEA 346_ DGISC 351_ SPAGA 356_ MGAQA 361_ SQDLG 366_ DELLD 371_ DGEDE 376_ EDEDE 381_ AWKAF 386_ NGGWT 391_ EMPGI 396_ LWMEP 401_ TQPPD 406_ FALAY 411_ RPSFP 416_ EDREP 421_ QIPYP 426_ EPTWP 431_ PPLSA 436_ PRVPY 441_ HSSVL 446_ SVTRP 451_ VVVSA 456_ THPTL 461_ PSAHQ 466_ PPVIP 471_ ATHPA 476_ LSRDH 481_ QIPVI 486_ AANYP 491_ DLPSA 496_ YQPGI 501_ LSVSH 506_ SAQPP 511_ AHQPP 516_ MISTK 521_ YPELF 526_ PAHQS 531_ PMFPD 536_ TRVAG 541_ TQTTT 546_ HLPGI 551_ PPNHA 556_ PLVTT 561_ LGAQL 566_ PPQAP 571_ DALVL 576_ RTQAT 581_ QLPII 586_ PTAQP 591_ SLTTT 596_ SRSPV 601_ SPAHQ 606_ ISVPA 611_ ATQPA 616_ ALPTL 621_ LPSQS 626_ PTNQT 631_ SPISP 636_ THPHS 641_ KAPQI 646_ PREDG 651_ PSPKL 656_ ALWLP 661_ SPAPT 666_ AAPTA 671_ LGEAG 676_ LAEHS 681_ QRDDR 686_ WLLVA 691_ LLVPT 696_ CVFLV 701_ VLLAL 706_ GIVYC 711_ TRCGP 716_ HAPNK 721_ RITDC 726_ YRWVI 731_ HAGSK 736_ SPTEP 741_ MPPRG 746_ SLTGV 751_QTCRT
1: Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway (PubMed:20484976). Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory response in macrophages by favoring the production of proinflammatory cytokines. In human, negatively regulates T-cell proliferation compared with stromal cells where it increases proliferation (PubMed:21466550)