Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12)
1_MGRRR 6_ APELY 11_ RAPFP 16_ LYALQ 21_ VDPST 26_ GLLIA 31_ AGGGG 36_ AAKTG 41_ IKNGV 46_ HFLQL 51_ ELING 56_ RLSAS 61_ LLHSH 66_ DTETR 71_ ATMNL 76_ ALAGD 81_ ILAAG 86_ QDAHC 91_ QLLRF 96_ QAHQQ 101_ QGNKA 106_ EKAGS 111_ KEQGP 116_ RQRKG 121_ AAPAE 126_ KKCGA 131_ ETQHE 136_ GLELR 141_ VENLQ 146_ AVQTD 151_ FSSDP 156_ LQKVV 161_ CFNHD 166_ NTLLA 171_ TGGTD 176_ GYVRV 181_ WKVPS 186_ LEKVL 191_ EFKAH 196_ EGEIE 201_ DLALG 206_ PDGKL 211_ VTVGR 216_ DLKAS 221_ VWQKD 226_ QLVTQ 231_ LHWQE 236_ NGPTF 241_ SSTPY 246_ RYQAC 251_ RFGQV 256_ PDQPA 261_ GLRLF 266_ TVQIP 271_ HKRLR 276_ QPPPC 281_ YLTAW 286_ DGSNF 291_ LPLRT 296_ KSCGH 301_ EVVSC 306_ LDVSE 311_ SGTFL 316_ GLGTV 321_ TGSVA 326_ IYIAF 331_ SLQCL 336_ YYVRE 341_ AHGIV 346_ VTDVA 351_ FLPEK 356_ GRGPE 361_ LLGSH 366_ ETALF 371_ SVAVD 376_ SRCQL 381_ HLLPS 386_ RRSVP 391_ VWLLL 396_ LLCVG 401_ LIIVT 406_ ILLLQ 411_SAFPG
1: Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:32358066). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:32358066)
2: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription