DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)
1_MGRKR 6_ LITDS 11_ YPVVK 16_ RREGP 21_ AGHSK 26_ GELAP 31_ ELGEE 36_ PQPRD 41_ EEEAE 46_ LELLR 51_ QFDLA 56_ WQYGP 61_ CTGIT 66_ RLQRW 71_ CRAKQ 76_ MGLEP 81_ PPEVW 86_ QVLKT 91_ HPGDP 96_ RFQCS 101_LWHLY
1: As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433). Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611). Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196). Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480)