Breast cancer metastasis-suppressor 1
1_MPVQP 6_ PSKDT 11_ EEMEA 16_ EGDSA 21_ AEMNG 26_ EEEES 31_ EEERS 36_ GSQTE 41_ SEEES 46_ SEMDD 51_ EDYER 56_ RRSEC 61_ VSEML 66_ DLEKQ 71_ FSELK 76_ EKLFR 81_ ERLSQ 86_ LRLRL 91_ EEVGA 96_ ERAPE 101_ YTEPL 106_ GGLQR 111_ SLKIR 116_ IQVAG 121_ IYKGF 126_ CLDVI 131_ RNKYE 136_ CELQG 141_ AKQHL 146_ ESEKL 151_ LLYDT 156_ LQGEL 161_ QERIQ 166_ RLEED 171_ RQSLD 176_ LSSEW 181_ WDDKL 186_ HARGS 191_ SRSWD 196_ SLPPS 201_ KRKKA 206_ PLVSG 211_ PYIVY 216_ MLQEI 221_ DILED 226_ WTAIK 231_ KARAA 236_ VSPQK 241_RKSDG
1: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma