Zinc finger protein 304 (KRAB-containing zinc finger protein)
1_MAAAV 6_ LMDRV 11_ QSCVT 16_ FEDVF 21_ VYFSR 26_ EEWEL 31_ LEEAQ 36_ RFLYR 41_ DVMLE 46_ NFALV 51_ ATLGF 56_ WCEAE 61_ HEAPS 66_ EQSVS 71_ VEGVS 76_ QVRTA 81_ ESGLF 86_ QKAHP 91_ CEMCD 96_ PLLKD 101_ ILHLA 106_ EHQGS 111_ HLTQK 116_ LCTRG 121_ LCRRR 126_ FSFSA 131_ NFYQH 136_ QKQHN 141_ GENCF 146_ RGDDG 151_ GASFV 156_ KSCTV 161_ HMLGR 166_ SFTCR 171_ EEGMD 176_ LPDSS 181_ GLFQH 186_ QTTYN 191_ RVSPC 196_ RRTEC 201_ MESFP 206_ HSSSL 211_ RQHQG 216_ DYDGQ 221_ MLFSC 226_ GDEGK 231_ AFLDT 236_ FTLLD 241_ SQMTH 246_ AEVRP 251_ FRCLP 256_ CGNVF 261_ KEKSA 266_ LINHR 271_ KIHSG 276_ EISHV 281_ CKECG 286_ KAFIH 291_ LHHLK 296_ MHQKF 301_ HTGKR 306_ HYTCS 311_ ECGKA 316_ FSRKD 321_ TLVQH 326_ QRVHT 331_ GERSY 336_ DCSEC 341_ GKAYS 346_ RSSHL 351_ VQHQR 356_ IHTGE 361_ RPYKC 366_ NKCGK 371_ AFSRK 376_ DTLVQ 381_ HQRFH 386_ TGERP 391_ YECSE 396_ CGKFF 401_ SQSSH 406_ LIEHW 411_ RIHTG 416_ ARPYE 421_ CIECG 426_ KFFSH 431_ NSSLI 436_ KHRRV 441_ HTGAR 446_ SYVCS 451_ KCGKA 456_ FGCKD 461_ TLVQH 466_ QIIHT 471_ GARPY 476_ ECSEC 481_ GKAFS 486_ RKDTL 491_ VQHQK 496_ IHTGE 501_ RPYEC 506_ GECGK 511_ FFSHS 516_ SNLIV 521_ HQRIH 526_ TGAKP 531_ YECNE 536_ CGKCF 541_ SHNSS 546_ LILHQ 551_ RVHTG 556_ ARPYV 561_ CSECG 566_ KAYIS 571_ SSHLV 576_ QHKKV 581_ HTGAR 586_ PYECS 591_ ECGKF 596_ FSRNS 601_ GLILH 606_ QRVHT 611_ GEKPY 616_ VCSEC 621_ GKAYS 626_ RSSHL 631_ VRHQK 636_ AHTGE 641_ RAHEC 646_ NSFGG 651_PLAAS
1: Acts as a transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979)