Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP)
1_MAELY 6_ VKPGN 11_ KERGW 16_ NDPPQ 21_ FSYGL 26_ QTQAG 31_ GPRRS 36_ LLTKR 41_ VAAPQ 46_ DGSPR 51_ VPASE 56_ TSPGP 61_ PPMGP 66_ PPPSS 71_ KAPRS 76_ PPVGS 81_ GPASG 86_ VEPTS 91_ FPVES 96_ EAVME 101_ DVLRP 106_ LEQAL 111_ EDCRG 116_ HTRKQ 121_ VCDDI 126_ SRRLA 131_ LLQEQ 136_ WAGGK 141_ LSIPV 146_ KKRMA 151_ LLVQE 156_ LSSHR 161_ WDAAD 166_ DIHRS 171_ LMVDH 176_ VTEVS 181_ QWMVG 186_ VKRLI 191_ AEKRS 196_ LFSEE 201_ AANEE 206_ KSAAT 211_ AEKNH 216_TIPGF
1: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis