Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST)
1_MSAGG 6_ PCPAA 11_ AGGGP 16_ GGASC 21_ SVGAP 26_ GGVSM 31_ FRWLE 36_ VLEKE 41_ FDKAF 46_ VDVDL 51_ LLGEI 56_ DPDQA 61_ DITYE 66_ GRQKM 71_ TSLSS 76_ CFAQL 81_ CHKAQ 86_ SVSQI 91_ NHKLE 96_ AQLVD 101_ LKSEL 106_ TETQA 111_ EKVVL 116_ EKEVH 121_ DQLLQ 126_ LHSIQ 131_ LQLHA 136_ KTGQS 141_ ADSGT 146_ IKAKL 151_ SGPSV 156_ EELER 161_ ELEAN 166_ KKEKM 171_ KEAQL 176_ EAEVK 181_ LLRKE 186_ NEALR 191_ RHIAV 196_ LQAEV 201_ YGARL 206_ AAKYL 211_ DKELA 216_ GRVQQ 221_ IQLLG 226_ RDMKG 231_ PAHDK 236_ LWNQL 241_ EAEIH 246_ LHRHK 251_ TVIRA 256_ CRGRN 261_ DLKRP 266_ MQAPP 271_ GHDQD 276_ SLKKS 281_ QGVGP 286_ IRKVL 291_ LLKED 296_ HEGLG 301_ ISITG 306_ GKEHG 311_ VPILI 316_ SEIHP 321_ GQPAD 326_ RCGGL 331_ HVGDA 336_ ILAVN 341_ GVNLR 346_ DTKHK 351_ EAVTI 356_ LSQQR 361_ GEIEF 366_ EVVYV 371_ APEVD 376_ SDDEN 381_ VEYED 386_ ESGHR 391_ YRLYL 396_ DELEG 401_ GGNPG 406_ ASCKD 411_ TSGEI 416_ KVLQG 421_ FNKKA 426_ VTDTH 431_ ENGDL 436_ GTASE 441_ TPLDD 446_ GASKL 451_ DDLHT 456_LYHKK
1: Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915)