Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein Boo) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B)
1_MVDQL 6_ RERTT 11_ MADPL 16_ RERTE 21_ LLLAD 26_ YLGYC 31_ AREPG 36_ TPEPA 41_ PSTPE 46_ AAVLR 51_ SAAAR 56_ LRQIH 61_ RSFFS 66_ AYLGY 71_ PGNRF 76_ ELVAL 81_ MADSV 86_ LSDSP 91_ GPTWG 96_ RVVTL 101_ VTFAG 106_ TLLER 111_ GPLVT 116_ ARWKK 121_ WGFQP 126_ RLKEQ 131_ EGDVA 136_ RDCQR 141_ LVALL 146_ SSRLM 151_ GQHRA 156_ WLQAQ 161_ GGWDG 166_ FCHFF 171_ RTPFP 176_ LAFWR 181_ KQLVQ 186_ AFLSC 191_ LLTTA 196_FIYLW
1: Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11278245, PubMed:11689480). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity)