Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)
1_MDDTL 6_ FQLKF 11_ TAKQL 16_ EKLAK 21_ KAEKD 26_ SKAEQ 31_ AKVKK 36_ ALLQK 41_ NVECA 46_ RVYAE 51_ NAIRK 56_ KNEGV 61_ NWLRM 66_ ASRVD 71_ AVASK 76_ VQTAV 81_ TMKGV 86_ TKNMA 91_ QVTKA 96_ LDKAL 101_ STMDL 106_ QKVSS 111_ VMDRF 116_ EQQVQ 121_ NLDVH 126_ TSVME 131_ DSMSS 136_ ATTLT 141_ TPQEQ 146_ VDSLI 151_ MQIAE 156_ ENGLE 161_ VLDQL 166_ SQLPE 171_ GASAV 176_ GESSV 181_ RSQED 186_ QLSRR 191_LAALR
1: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing