Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)
1_MAGAG 6_ GGLGV 11_ WGNLV 16_ LLGLC 21_ SWTGA 26_ RAPAP 31_ NPGRN 36_ LTVET 41_ QTTSS 46_ ISLSW 51_ EVPDG 56_ LDSQN 61_ SNYWV 66_ QCTGD 71_ GGTTE 76_ TRNTT 81_ ATNVT 86_ VDGLG 91_ PGSLY 96_ TCSVW 101_ VEKDG 106_ VNSSV 111_ GTVTT 116_ ATAPN 121_ PVRNL 126_ RVEAQ 131_ TNSSI 136_ ALTWE 141_ VPDGP 146_ DPQNS 151_ TYGVE 156_ YTGDG 161_ GRAGT 166_ RSTAH 171_ TNITV 176_ DGLEP 181_ GCLYA 186_ FSMWV 191_ GKNGI 196_ NSSRE 201_ TRNAT 206_ TAHNP 211_ VRNLR 216_ VEAQT 221_ TSSIS 226_ LSWEV 231_ PDGTD 236_ PQNST 241_ YCVQC 246_ TGDGG 251_ RTETR 256_ NTTDT 261_ RVTVD 266_ GLGPG 271_ SLYTC 276_ SVWVE 281_ KDGVN 286_ SSVEI 291_ VTSAT 296_ APNPV 301_ RNLTV 306_ EAQTN 311_ SSIAL 316_ TWEVP 321_ DGPDP 326_ QNSTY 331_ GVEYT 336_ GDGGR 341_ AGTRS 346_ TAHTN 351_ ITVDR 356_ LEPGC 361_ LYVFS 366_ VWVGK 371_ NGINS 376_ SRETR 381_ NATTA 386_ PNPVR 391_ NLHME 396_ TQTNS 401_ SIALC 406_ WEVPD 411_ GPYPQ 416_ DYTYW 421_ VEYTG 426_ DGGGT 431_ ETRNT 436_ TNTSV 441_ TAERL 446_ EPGTL 451_ YTFSV 456_ WAEKN 461_ GARGS 466_ RQNVS 471_ ISTVP 476_ NAVTS 481_ LSKQD 486_ WTNST 491_ IALRW 496_ TAPQG 501_ PGQSS 506_ YSYWV 511_ SWVRE 516_ GMTDP 521_ RTQST 526_ SGTDI 531_ TLKEL 536_ EAGSL 541_ YHLTV 546_ WAERN 551_ EVRGY 556_ NSTLT 561_ AATAP 566_ NEVTD 571_ LQNET 576_ QTKNS 581_ VMLWW 586_ KAPGD 591_ PHSQL 596_ YVYWV 601_ QWASK 606_ GHPRR 611_ GQDPQ 616_ ANWVN 621_ QTSRT 626_ NETWY 631_ KVEAL 636_ EPGTL 641_ YNFTV 646_ WAERN 651_ DVASS 656_ TQSLC 661_ ASTYP 666_ DTVTI 671_ TSCVS 676_ TSAGY 681_ GVNLI 686_ WSCPQ 691_ GGYEA 696_ FELEV 701_ GGQRG 706_ SQDRS 711_ SCGEA 716_ VSVLG 721_ LGPAR 726_ SYPAT 731_ ITTIW 736_ DGMKV 741_ VSHSV 746_ VCHTE 751_ SAGVI 756_ AGAFV 761_ GILLF 766_ LILVG 771_ LLIFF 776_ LKRRN 781_ KKKQQ 786_ KPELR 791_ DLVFS 796_ SPGDI 801_ PAEDF 806_ ADHVR 811_ KNERD 816_ SNCGF 821_ ADEYQ 826_ QLSLV 831_ GHSQS 836_ QMVAS 841_ ASENN 846_ AKNRY 851_ RNVLP 856_ YDWSR 861_ VPLKP 866_ IHEEP 871_ GSDYI 876_ NASFM 881_ PGLWS 886_ PQEFI 891_ ATQGP 896_ LPQTV 901_ GDFWR 906_ LVWEQ 911_ QSHTL 916_ VMLTN 921_ CMEAG 926_ RVKCE 931_ HYWPL 936_ DSQPC 941_ THGHL 946_ RVTLV 951_ GEEVM 956_ ENWTV 961_ RELLL 966_ LQVEE 971_ QKTLS 976_ VRQFH 981_ YQAWP 986_ DHGVP 991_ SSPDT 996_ LLAFW 1001_ RMLRQ 1006_ WLDQT 1011_ MEGGP 1016_ PIVHC 1021_ SAGVG 1026_ RTGTL 1031_ IALDV 1036_ LLRQL 1041_ QSEGL 1046_ LGPFS 1051_ FVRKM 1056_ RESRP 1061_ LMVQT 1066_ EAQYV 1071_ FLHQC 1076_ ILRFL 1081_ QQSAQ 1086_ APAEK 1091_ EVPYE 1096_ DVENL 1101_ IYENV 1106_AAIQA
1: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity)