Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1)
1_MEPTR 6_ DCPLF 11_ GGAFS 16_ AILPM 21_ GAIDV 26_ SDLRP 31_ VPDNQ 36_ EVFCH 41_ PVTDQ 46_ SLIVE 51_ LLELQ 56_ AHVRG 61_ EAAAR 66_ YHFED 71_ VGGVQ 76_ GARAV 81_ HVESV 86_ QPLSL 91_ ENLAL 96_ RGRCQ 101_ EAWVL 106_ SGKQQ 111_ IAKEN 116_ QQVAK 121_ DVTLH 126_ QALLR 131_ LPQYQ 136_ TDLLL 141_ TFNQP 146_ PPDNR 151_ SSLGP 156_ ENLSP 161_ APWSL 166_ GDFEQ 171_ LVTSL 176_ TLHDP 181_NIFGP
1: May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:21621375, PubMed:23420830)