Unconventional myosin-X (Unconventional myosin-10)
1_MDNFF 6_ TEGTR 11_ VWLRE 16_ NGQHF 21_ PSTVN 26_ SCAEG 31_ IVVFR 36_ TDYGQ 41_ VFTYK 46_ QSTIT 51_ HQKVT 56_ AMHPT 61_ NEEGV 66_ DDMAS 71_ LTELH 76_ GGSIM 81_ YNLFQ 86_ RYKRN 91_ QIYTY 96_ IGSIL 101_ ASVNP 106_ YQPIA 111_ GLYEP 116_ ATMEQ 121_ YSRRH 126_ LGELP 131_ PHIFA 136_ IANEC 141_ YRCLW 146_ KRHDN 151_ QCILI 156_ SGESG 161_ AGKTE 166_ STKLI 171_ LKFLS 176_ VISQQ 181_ SLELS 186_ LKEKT 191_ SCVER 196_ AILES 201_ SPIME 206_ AFGNA 211_ KTVYN 216_ NNSSR 221_ FGKFV 226_ QLNIC 231_ QKGNI 236_ QGGRI 241_ VDYLL 246_ EKNRV 251_ VRQNP 256_ GERNY 261_ HIFYA 266_ LLAGL 271_ EHEER 276_ EEFYL 281_ STPEN 286_ YHYLN 291_ QSGCV 296_ EDKTI 301_ SDQES 306_ FREVI 311_ TAMDV 316_ MQFSK 321_ EEVRE 326_ VSRLL 331_ AGILH 336_ LGNIE 341_ FITAG 346_ GAQVS 351_ FKTAL 356_ GRSAE 361_ LLGLD 366_ PTQLT 371_ DALTQ 376_ RSMFL 381_ RGEEI 386_ LTPLN 391_ VQQAV 396_ DSRDS 401_ LAMAL 406_ YACCF 411_ EWVIK 416_ KINSR 421_ IKGNE 426_ DFKSI 431_ GILDI 436_ FGFEN 441_ FEVNH 446_ FEQFN 451_ INYAN 456_ EKLQE 461_ YFNKH 466_ IFSLE 471_ QLEYS 476_ REGLV 481_ WEDID 486_ WIDNG 491_ ECLDL 496_ IEKKL 501_ GLLAL 506_ INEES 511_ HFPQA 516_ TDSTL 521_ LEKLH 526_ SQHAN 531_ NHFYV 536_ KPRVA 541_ VNNFG 546_ VKHYA 551_ GEVQY 556_ DVRGI 561_ LEKNR 566_ DTFRD 571_ DLLNL 576_ LRESR 581_ FDFIY 586_ DLFEH 591_ VSSRN 596_ NQDTL 601_ KCGSK 606_ HRRPT 611_ VSSQF 616_ KDSLH 621_ SLMAT 626_ LSSSN 631_ PFFVR 636_ CIKPN 641_ MQKMP 646_ DQFDQ 651_ AVVLN 656_ QLRYS 661_ GMLET 666_ VRIRK 671_ AGYAV 676_ RRPFQ 681_ DFYKR 686_ YKVLM 691_ RNLAL 696_ PEDVR 701_ GKCTS 706_ LLQLY 711_ DASNS 716_ EWQLG 721_ KTKVF 726_ LRESL 731_ EQKLE 736_ KRREE 741_ EVSHA 746_ AMVIR 751_ AHVLG 756_ FLARK 761_ QYRKV 766_ LYCVV 771_ IIQKN 776_ YRAFL 781_ LRRRF 786_ LHLKK 791_ AAIVF 796_ QKQLR 801_ GQIAR 806_ RVYRQ 811_ LLAEK 816_ REQEE 821_ KKKQE 826_ EEEKK 831_ KREEE 836_ ERERE 841_ RERRE 846_ AELRA 851_ QQEEE 856_ TRKQQ 861_ ELEAL 866_ QKSQK 871_ EAELT 876_ RELEK 881_ QKENK 886_ QVEEI 891_ LRLEK 896_ EIEDL 901_ QRMKE 906_ QQELS 911_ LTEAS 916_ LQKLQ 921_ ERRDQ 926_ ELRRL 931_ EEEAC 936_ RAAQE 941_ FLESL 946_ NFDEI 951_ DECVR 956_ NIERS 961_ LSVGS 966_ EFSSE 971_ LAESA 976_ CEEKP 981_ NFNFS 986_ QPYPE 991_ EEVDE 996_ GFEAD 1001_ DDAFK 1006_ DSPNP 1011_ SEHGH 1016_ SDQRT 1021_ SGIRT 1026_ SDDSS 1031_ EEDPY 1036_ MNDTV 1041_ VPTSP 1046_ SADST 1051_ VLLAP 1056_ SVQDS 1061_ GSLHN 1066_ SSSGE 1071_ STYCM 1076_ PQNAG 1081_ DLPSP 1086_ DGDYD 1091_ YDQDD 1096_ YEDGA 1101_ ITSGS 1106_ SVTFS 1111_ NSYGS 1116_ QWSPD 1121_ YRCSV 1126_ GTYNS 1131_ SGAYR 1136_ FSSEG 1141_ AQSSF 1146_ EDSEE 1151_ DFDSR 1156_ FDTDD 1161_ ELSYR 1166_ RDSVY 1171_ SCVTL 1176_ PYFHS 1181_ FLYMK 1186_ GGLMN 1191_ SWKRR 1196_ WCVLK 1201_ DETFL 1206_ WFRSK 1211_ QEALK 1216_ QGWLH 1221_ KKGGG 1226_ SSTLS 1231_ RRNWK 1236_ KRWFV 1241_ LRQSK 1246_ LMYFE 1251_ NDSEE 1256_ KLKGT 1261_ VEVRT 1266_ AKEII 1271_ DNTTK 1276_ ENGID 1281_ IIMAD 1286_ RTFHL 1291_ IAESP 1296_ EDASQ 1301_ WFSVL 1306_ SQVHA 1311_ STDQE 1316_ IQEMH 1321_ DEQAN 1326_ PQNAV 1331_ GTLDV 1336_ GLIDS 1341_ VCASD 1346_ SPDRP 1351_ NSFVI 1356_ ITANR 1361_ VLHCN 1366_ ADTPE 1371_ EMHHW 1376_ ITLLQ 1381_ RSKGD 1386_ TRVEG 1391_ QEFIV 1396_ RGWLH 1401_ KEVKN 1406_ SPKMS 1411_ SLKLK 1416_ KRWFV 1421_ LTHNS 1426_ LDYYK 1431_ SSEKN 1436_ ALKLG 1441_ TLVLN 1446_ SLCSV 1451_ VPPDE 1456_ KIFKE 1461_ TGYWN 1466_ VTVYG 1471_ RKHCY 1476_ RLYTK 1481_ LLNEA 1486_ TRWSS 1491_ AIQNV 1496_ TDTKA 1501_ PIDTP 1506_ TQQLI 1511_ QDIKE 1516_ NCLNS 1521_ DVVEQ 1526_ IYKRN 1531_ PILRY 1536_ THHPL 1541_ HSPLL 1546_ PLPYG 1551_ DINLN 1556_ LLKDK 1561_ GYTTL 1566_ QDEAI 1571_ KIFNS 1576_ LQQLE 1581_ SMSDP 1586_ IPIIQ 1591_ GILQT 1596_ GHDLR 1601_ PLRDE 1606_ LYCQL 1611_ IKQTN 1616_ KVPHP 1621_ GSVGN 1626_ LYSWQ 1631_ ILTCL 1636_ SCTFL 1641_ PSRGI 1646_ LKYLK 1651_ FHLKR 1656_ IREQF 1661_ PGSEM 1666_ EKYAL 1671_ FTYES 1676_ LKKTK 1681_ CREFV 1686_ PSRDE 1691_ IEALI 1696_ HRQEM 1701_ TSTVY 1706_ CHGGG 1711_ SCKIT 1716_ INSHT 1721_ TAGEV 1726_ VEKLI 1731_ RGLAM 1736_ EDSRN 1741_ MFALF 1746_ EYNGH 1751_ VDKAI 1756_ ESRTV 1761_ VADVL 1766_ AKFEK 1771_ LAATS 1776_ EVGDL 1781_ PWKFY 1786_ FKLYC 1791_ FLDTD 1796_ NVPKD 1801_ SVEFA 1806_ FMFEQ 1811_ AHEAV 1816_ IHGHH 1821_ PAPEE 1826_ NLQVL 1831_ AALRL 1836_ QYLQG 1841_ DYTLH 1846_ AAIPP 1851_ LEEVY 1856_ SLQRL 1861_ KARIS 1866_ QSTKT 1871_ FTPCE 1876_ RLEKR 1881_ RTSFL 1886_ EGTLR 1891_ RSFRT 1896_ GSVVR 1901_ QKVEE 1906_ EQMLD 1911_ MWIKE 1916_ EVSSA 1921_ RASII 1926_ DKWRK 1931_ FQGMN 1936_ QEQAM 1941_ AKYMA 1946_ LIKEW 1951_ PGYGS 1956_ TLFDV 1961_ ECKEG 1966_ GFPQE 1971_ LWLGV 1976_ SADAV 1981_ SVYKR 1986_ GEGRP 1991_ LEVFQ 1996_ YEHIL 2001_ SFGAP 2006_ LANTY 2011_ KIVVD 2016_ ERELL 2021_ FETSE 2026_ VVDVA 2031_ KLMKA 2036_ YISMI 2041_ VKKRY 2046_ STTRS 2051_ASSQG
1: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts
2: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity)