Endogenous retrovirus group K member 5 Gag polyprotein (HERV-K(II) Gag protein) (HERV-K_3q12.3 provirus ancestral Gag polyprotein) (Gag polyprotein)
1_MGQTK 6_ SKTKS 11_ KYASY 16_ LSFIK 21_ ILLKR 26_ GGVRV 31_ STKNL 36_ IKLFQ 41_ IIEQF 46_ CPWFP 51_ EQGTL 56_ DLKDW 61_ KRIGE 66_ ELKQA 71_ GRKGN 76_ IIPLT 81_ VWNDW 86_ AIIKA 91_ ALEPF 96_ QTKED 101_ SVSVS 106_ DAPGS 111_ CVIDC 116_ NEKTG 121_ RKSQK 126_ ETESL 131_ HCEYV 136_ TEPVM 141_ AQSTQ 146_ NVDYN 151_ QLQGV 156_ IYPET 161_ LKLEG 166_ KGPEL 171_ VGPSE 176_ SKPRG 181_ PSPLP 186_ AGQVP 191_ VTLQP 196_ QTQVK 201_ ENKTQ 206_ PPVAY 211_ QYWPP 216_ AELQY 221_ LPPPE 226_ SQYGY 231_ PGMPP 236_ ALQGR 241_ APYPQ 246_ PPTVR 251_ LNPTA 256_ SRSGQ 261_ GGTLH 266_ AVIDE 271_ ARKQG 276_ DLEAW 281_ RFLVI 286_ LQLVQ 291_ AGEET 296_ QVGAP 301_ ARAET 306_ RCEPF 311_ TMKML 316_ KDIKE 321_ GVKQY 326_ GSNSP 331_ YIRTL 336_ LDSIA 341_ HGNRL 346_ TPYDW 351_ ESLAK 356_ SSLSS 361_ SQYLQ 366_ FKTWW 371_ IDGVQ 376_ EQVRK 381_ NQATK 386_ PTVNI 391_ DADQL 396_ LGTGP 401_ NWSTI 406_ NQQSV 411_ MQNEA 416_ IEQVR 421_ AICLR 426_ AWGKI 431_ QDPGT 436_ AFPIN 441_ SIRQG 446_ SKEPY 451_ PDFVA 456_ RLQDA 461_ AQKSI 466_ TDDNA 471_ RKVIV 476_ ELMAY 481_ ENANP 486_ ECQSA 491_ IKPLK 496_ GKVPA 501_ GVDVI 506_ TEYVK 511_ ACDGI 516_ GGAMH 521_ KAMLM 526_ AQAMR 531_ GLTLG 536_ GQVRT 541_ FGKKC 546_ YNCGQ 551_ IGHLK 556_ RSCPV 561_ LNKQN 566_ IINQA 571_ ITAKN 576_ KKPSG 581_ LCPKC 586_ GKGKH 591_ WANQC 596_ HSKFD 601_ KDGQP 606_ LSGNR 611_ KRGQP 616_ QAPQQ 621_ TGAFP 626_ VQLFV 631_ PQGFQ 636_ GQQPL 641_ QKIPP 646_ LQGVS 651_ QLQQS 656_ NSCPA 661_PQQAA
1: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution