Phospholipase A and acyltransferase 1 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 1) (HRSL1) (Phospholipid-metabolizing enzyme A-C1)
1_MAFND 6_ CFSLN 11_ YPGNP 16_ CPGDL 21_ IEVFR 26_ PGYQH 31_ WALYL 36_ GDGYV 41_ INIAP 46_ VDGIP 51_ ASFTS 56_ AKSVF 61_ SSKAL 66_ VKMQL 71_ LKDVV 76_ GNDTY 81_ RINNK 86_ YDETY 91_ PPLPV 96_ EEIIK 101_ RSEFV 106_ IGQEV 111_ AYNLL 116_ VNNCE 121_ HFVTL 126_ LRYGE 131_ GVSEQ 136_ ANRAI 141_ STVEF 146_ VTAAV 151_ GVFSF 156_ LGLFP 161_KGQRA
1: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847)