HERV-H_2q24.1 provirus ancestral Env polyprotein (Env protein HERV-H/p59) (Envelope polyprotein) (HERV-H/env59) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
1_MILAG 6_ RAPSN 11_ TSTLM 16_ KFYSL 21_ LLYSL 26_ LFSFP 31_ FLYHP 36_ LPLPS 41_ YLHHT 46_ INLTH 51_ SLPAA 56_ SNPSL 61_ ANNCW 66_ LCISL 71_ SSSAY 76_ IAVPT 81_ LQTDR 86_ ATSPV 91_ SLHLR 96_ TSFNS 101_ PHLYP 106_ PEELI 111_ YFLDR 116_ SSKTS 121_ PDISH 126_ QPAAA 131_ LLHIY 136_ LKNLS 141_ PYINS 146_ TPPIF 151_ GPLTT 156_ QTTIP 161_ VAAPL 166_ CISRQ 171_ RPTGI 176_ PLGNI 181_ SPSRC 186_ SFTLH 191_ LQSPT 196_ THVTE 201_ TIGVF 206_ QLHII 211_ DKPSI 216_ NTDKL 221_ KNVSS 226_ NYCLG 231_ RHLPY 236_ ISLHP 241_ WLPSP 246_ CSSDS 251_ PPRPS 256_ SCLLT 261_ PSPQN 266_ NSERL 271_ LVDTQ 276_ RFLIH 281_ HENRT 286_ SSSMQ 291_ LAHQS 296_ PLQPL 301_ TAAAL 306_ AGSLG 311_ VWVQD 316_ TPFST 321_ PSHPF 326_ SLHLQ 331_ FCLTQ 336_ GLFFL 341_ CGSST 346_ YMCLP 351_ ANWTG 356_ TCTLV 361_ FLTPK 366_ IQFAN 371_ GTKEL 376_ PVPLM 381_ TLTPQ 386_ KRVIP 391_ LIPLM 396_ VGLGL 401_ SASTI 406_ ALSTG 411_ IAGIS 416_ TSVTT 421_ FRSPS 426_ NDFSA 431_ SITDI 436_ SQTLS 441_ VLQAQ 446_ VDSLA 451_ AVVLQ 456_ NRRGL 461_ GLSIL 466_ LNEEC 471_ CFYLN 476_ QSGLV 481_ YENIK 486_ KLKDR 491_ AQKLA 496_ NQASN 501_ YAESP 506_ WALSN 511_ WMSWV 516_ LPILS 521_ PLIPI 526_ FLLLL 531_ FGPCI 536_ FHLVS 541_ QFIQN 546_RIQAI
1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties
2: SU mediates receptor recognition
3: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)