HERV-H_2q24.3 provirus ancestral Env polyprotein (Env protein HERV-H/p62) (Env protein HERV-H19) (Env protein HERV-Hcl.3) (Envelope polyprotein) (HERV-H/env62) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
1_MIFAG 6_ KAPSN 11_ TSTLM 16_ KFYSL 21_ LLYSL 26_ LFSFP 31_ FLCHP 36_ LPLPS 41_ YLHHT 46_ INLTH 51_ SLLAA 56_ SNPSL 61_ VNNCW 66_ LCISL 71_ SSSAY 76_ TAVPA 81_ VQTDW 86_ ATSPI 91_ SLHLR 96_ TSFNS 101_ PHLYP 106_ PEELI 111_ YFLDR 116_ SSKTS 121_ PDISH 126_ QQAAA 131_ LLRTY 136_ LKNLS 141_ PYINS 146_ TPPIF 151_ GPLTT 156_ QTTIP 161_ VAAPL 166_ CISWQ 171_ RPTGI 176_ PLGNL 181_ SPSRC 186_ SFTLH 191_ LRSPT 196_ TNINE 201_ TIGAF 206_ QLHIT 211_ DKPSI 216_ NTDKL 221_ KNISS 226_ NYCLG 231_ RHLPC 236_ ISLHP 241_ WLSSP 246_ CSSDS 251_ PPRPS 256_ SCLLI 261_ PSPEN 266_ NSERL 271_ LVDTR 276_ RFLIH 281_ HENRT 286_ FPSTQ 291_ LPHQS 296_ PLQPL 301_ TAAAL 306_ AGSLG 311_ VWVQD 316_ TPFST 321_ PSHLF 326_ TLHLQ 331_ FCLAQ 336_ GLFFL 341_ CGSST 346_ YMCLP 351_ ANWTG 356_ TCTLV 361_ FLTPK 366_ IQFAN 371_ GTEEL 376_ PVPLM 381_ TPTQQ 386_ KRVIP 391_ LIPLM 396_ VGLGL 401_ SASTV 406_ ALGTG 411_ IAGIS 416_ TSVMT 421_ FRSLS 426_ NDFSA 431_ SITDI 436_ SQTLS 441_ VLQAQ 446_ VDSLA 451_ AVVLQ 456_ NRRGL 461_ DLLTA 466_ EKGGL 471_ CIFLN 476_ EECCF 481_ YLNQS 486_ GLVYD 491_ NIKKL 496_ KDRAQ 501_ KLANQ 506_ ASNYA 511_ EPPWA 516_ LSNWM 521_ SWVLP 526_ IVSPL 531_ IPIFL 536_ LLLFG 541_ PCIFR 546_ LVSQF 551_ IQNRI 556_ QAITN 561_ HSIRQ 566_ MFLLT 571_ SPQYH 576_PLPQD
1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties but has immunosuppressive properties in vivo
2: SU mediates receptor recognition
3: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)