SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein homolog)
1_MFGFH 6_ KPKMY 11_ RSIEG 16_ CCICR 21_ AKSSS 26_ SRFTD 31_ SKRYE 36_ KDFQS 41_ CFGLH 46_ ETRSG 51_ DICNA 56_ CVLLV 61_ KRWKK 66_ LPAGS 71_ KKNWN 76_ HVVDA 81_ RAGPS 86_ LKTTL 91_ KPKKV 96_ KTLSG 101_ NRIKS 106_ NQISK 111_ LQKEF 116_ KRHNS 121_ DAHST 126_ TSSAS 131_ PAQSP 136_ CYSNQ 141_ SDDGS 146_ DTEMA 151_ SGSNR 156_ TPVFS 161_ FLDLT 166_ YWKRQ 171_ KICCG 176_ IIYKG 181_ RFGEV 186_ LIDTH 191_ LFKPC 196_ CSNKK 201_ AAAEK 206_ PEEQG 211_ PEPLP 216_ISTQE
1: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity)