BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl)
1_MFQTG 6_ GLIVF 11_ YGLLA 16_ QTMAQ 21_ FGGLP 26_ VPLDQ 31_ TLPLN 36_ VNPAL 41_ PLSPT 46_ GLAGS 51_ LTNAL 56_ SNGLL 61_ SGGLL 66_ GILEN 71_ LPLLD 76_ ILKPG 81_ GGTSG 86_ GLLGG 91_ LLGKV 96_ TSVIP 101_ GLNNI 106_ IDIKV 111_ TDPQL 116_ LELGL 121_ VQSPD 126_ GHRLY 131_ VTIPL 136_ GIKLQ 141_ VNTPL 146_ VGASL 151_ LRLAV 156_ KLDIT 161_ AEILA 166_ VRDKQ 171_ ERIHL 176_ VLGDC 181_ THSPG 186_ SLQIS 191_ LLDGL 196_ GPLPI 201_ QGLLD 206_ SLTGI 211_ LNKVL 216_ PELVQ 221_ GNVCP 226_ LVNEV 231_ LRGLD 236_ ITLVH 241_ DIVNM 246_ LIHGL 251_QFVIK
1: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608). Plays a role in the innate immune responses of the upper airways (PubMed:23132494, PubMed:23499554). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23132494, PubMed:23499554, PubMed:27145151). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24043776, PubMed:24124190). Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234). May attract macrophages and neutrophils (PubMed:23132494)