ATP-binding cassette sub-family B member 6 (ABC-type heme transporter ABCB6) (EC 7.6.2.5) (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter)
1_MVTVG 6_ NYCEA 11_ EGPVG 16_ PAWMQ 21_ DGLSP 26_ CFFFT 31_ LVPST 36_ RMALG 41_ TLALV 46_ LALPC 51_ RRRER 56_ PAGAD 61_ SLSWG 66_ AGPRI 71_ SPYVL 76_ QLLLA 81_ TLQAA 86_ LPLAG 91_ LAGRV 96_ GTARG 101_ APLPS 106_ YLLLA 111_ SVLES 116_ LAGAC 121_ GLWLL 126_ VVERS 131_ QARQR 136_ LAMGI 141_ WIKFR 146_ HSPGL 151_ LLLWT 156_ VAFAA 161_ ENLAL 166_ VSWNS 171_ PQWWW 176_ ARADL 181_ GQQVQ 186_ FSLWV 191_ LRYVV 196_ SGGLF 201_ VLGLW 206_ APGLR 211_ PQSYT 216_ LQVHE 221_ EDQDV 226_ ERSQV 231_ RSAAQ 236_ QSTWR 241_ DFGRK 246_ LRLLS 251_ GYLWP 256_ RGSPA 261_ LQLVV 266_ LICLG 271_ LMGLE 276_ RALNV 281_ LVPIF 286_ YRNIV 291_ NLLTE 296_ KAPWN 301_ SLAWT 306_ VTSYV 311_ FLKFL 316_ QGGGT 321_ GSTGF 326_ VSNLR 331_ TFLWI 336_ RVQQF 341_ TSRRV 346_ ELLIF 351_ SHLHE 356_ LSLRW 361_ HLGRR 366_ TGEVL 371_ RIADR 376_ GTSSV 381_ TGLLS 386_ YLVFN 391_ VIPTL 396_ ADIII 401_ GIIYF 406_ SMFFN 411_ AWFGL 416_ IVFLC 421_ MSLYL 426_ TLTIV 431_ VTEWR 436_ TKFRR 441_ AMNTQ 446_ ENATR 451_ ARAVD 456_ SLLNF 461_ ETVKY 466_ YNAES 471_ YEVER 476_ YREAI 481_ IKYQG 486_ LEWKS 491_ SASLV 496_ LLNQT 501_ QNLVI 506_ GLGLL 511_ AGSLL 516_ CAYFV 521_ TEQKL 526_ QVGDY 531_ VLFGT 536_ YIIQL 541_ YMPLN 546_ WFGTY 551_ YRMIQ 556_ TNFID 561_ MENMF 566_ DLLKE 571_ ETEVK 576_ DLPGA 581_ GPLRF 586_ QKGRI 591_ EFENV 596_ HFSYA 601_ DGRET 606_ LQDVS 611_ FTVMP 616_ GQTLA 621_ LVGPS 626_ GAGKS 631_ TILRL 636_ LFRFY 641_ DISSG 646_ CIRID 651_ GQDIS 656_ QVTQA 661_ SLRSH 666_ IGVVP 671_ QDTVL 676_ FNDTI 681_ ADNIR 686_ YGRVT 691_ AGNDE 696_ VEAAA 701_ QAAGI 706_ HDAIM 711_ AFPEG 716_ YRTQV 721_ GERGL 726_ KLSGG 731_ EKQRV 736_ AIART 741_ ILKAP 746_ GIILL 751_ DEATS 756_ ALDTS 761_ NERAI 766_ QASLA 771_ KVCAN 776_ RTTIV 781_ VAHRL 786_ STVVN 791_ ADQIL 796_ VIKDG 801_ CIVER 806_ GRHEA 811_ LLSRG 816_ GVYAD 821_ MWQLQ 826_ QGQEE 831_ TSEDT 836_KPQTM
1: ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:17661442, PubMed:23792964, PubMed:27507172, PubMed:33007128). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:10837493, PubMed:17006453, PubMed:23792964, PubMed:33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed:29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed:21266531, PubMed:25202056, PubMed:31053883). In addition may play a role in the transition metal homeostasis (By similarity)