Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
1_MTRAG 6_ DHNRQ 11_ RGCCG 16_ SLADY 21_ LTSAK 26_ FLLYL 31_ GHSLS 36_ TWGDR 41_ MWHFA 46_ VSVFL 51_ VELYG 56_ NSLLL 61_ TAVYG 66_ LVVAG 71_ SVLVL 76_ GAIIG 81_ DWVDK 86_ NARLK 91_ VAQTS 96_ LVVQN 101_ VSVIL 106_ CGIIL 111_ MMVFL 116_ HKHEL 121_ LTMYH 126_ GWVLT 131_ SCYIL 136_ IITIA 141_ NIANL 146_ ASTAT 151_ AITIQ 156_ RDWIV 161_ VVAGE 166_ DRSKL 171_ ANMNA 176_ TIRRI 181_ DQLTN 186_ ILAPM 191_ AVGQI 196_ MTFGS 201_ PVIGC 206_ GFISG 211_ WNLVS 216_ MCVEY 221_ VLLWK 226_ VYQKT 231_ PALAV 236_ KAGLK 241_ EEETE 246_ LKQLN 251_ LHKDT 256_ EPKPL 261_ EGTHL 266_ MGVKD 271_ SNIHE 276_ LEHEQ 281_ EPTCA 286_ SQMAE 291_ PFRTF 296_ RDGWV 301_ SYYNQ 306_ PVFLA 311_ GMGLA 316_ FLYMT 321_ VLGFD 326_ CITTG 331_ YAYTQ 336_ GLSGS 341_ ILSIL 346_ MGASA 351_ ITGIM 356_ GTVAF 361_ TWLRR 366_ KCGLV 371_ RTGLI 376_ SGLAQ 381_ LSCLI 386_ LCVIS 391_ VFMPG 396_ SPLDL 401_ SVSPF 406_ EDIRS 411_ RFIQG 416_ ESITP 421_ TKIPE 426_ ITTEI 431_ YMSNG 436_ SNSAN 441_ IVPET 446_ SPESV 451_ PIISV 456_ SLLFA 461_ GVIAA 466_ RIGLW 471_ SFDLT 476_ VTQLL 481_ QENVI 486_ ESERG 491_ IINGV 496_ QNSMN 501_ YLLDL 506_ LHFIM 511_ VILAP 516_ NPEAF 521_ GLLVL 526_ ISVSF 531_ VAMGH 536_ IMYFR 541_ FAQNT 546_ LGNKL 551_ FACGP 556_ DAKEV 561_ RKENQ 566_ANTSV
1: Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:22178646, PubMed:22682227, PubMed:24304836, PubMed:29237594, PubMed:29599243, PubMed:30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342)