Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)
1_MAGAL 6_ AGLAA 11_ GLQVP 16_ RVAPS 21_ PDSDS 26_ DTDSE 31_ DPSLR 36_ RSAGG 41_ LLRSQ 46_ VIHSG 51_ HFMVS 56_ SPHSD 61_ SLPRR 66_ RDQEG 71_ SVGPS 76_ DFGPR 81_ SIDPT 86_ LTRLF 91_ ECLSL 96_ AYSGK 101_ LVSPK 106_ WKNFK 111_ GLKLL 116_ CRDKI 121_ RLNNA 126_ IWRAW 131_ YIQYV 136_ KRRKS 141_ PVCGF 146_ VTPLQ 151_ GPEAD 156_ AHRKP 161_ EAVVL 166_ EGNYW 171_ KRRIE 176_ VVMRE 181_ YHKWR 186_ IYYKK 191_ RLRKP 196_ SREDD 201_ LLAPK 206_ QAEGR 211_ WPPPE 216_ QWCKQ 221_ LFSSV 226_ VPVLL 231_ GDPEE 236_ EPGGR 241_ QLLDL 246_ NCFLS 251_ DISDT 256_ LFTMT 261_ QSGPS 266_ PLQLP 271_ PEDAY 276_ VGNAD 281_ MIQPD 286_ LTPLQ 291_ PSLDD 296_ FMDIS 301_ DFFTN 306_ SRLPQ 311_ PPMPS 316_ NFPEP 321_ PSFSP 326_ VVDSL 331_ FSSGT 336_ LGPEV 341_ PPASS 346_ AMTHL 351_ SGHSR 356_ LQARN 361_ SCPGP 366_ LDSSA 371_ FLSSD 376_ FLLPE 381_ DPKPR 386_ LPPPP 391_ VPPPL 396_ LHYPP 401_ PAKVP 406_ GLEPC 411_ PPPPF 416_ PPMAP 421_ PTALL 426_ QEEPL 431_ FSPRF 436_ PFPTV 441_ PPAPG 446_ VSPLP 451_ APAAF 456_ PPTPQ 461_ SVPSP 466_ APTPF 471_ PIELL 476_ PLGYS 481_ EPAFG 486_ PCFSM 491_ PRGKP 496_ PAPSP 501_ RGQKA 506_ SPPTL 511_ APATA 516_ SPPTT 521_ AGSNN 526_ PCLTQ 531_ LLTAA 536_ KPEQA 541_ LEPPL 546_ VSSTL 551_ LRSPG 556_ SPQET 561_ VPEFP 566_ CTFLP 571_ PTPAP 576_ TPPRP 581_ PPGPA 586_ TLAPS 591_ RPLLV 596_ PKAER 601_ LSPPA 606_ PSGSE 611_ RRLSG 616_ DLSSM 621_ PGPGT 626_ LSVRV 631_ SPPQP 636_ ILSRG 641_ RPDSN 646_ KTENR 651_ RITHI 656_ SAEQK 661_ RRFNI 666_ KLGFD 671_ TLHGL 676_ VSTLS 681_ AQPSL 686_ KVSKA 691_ TTLQK 696_ TAEYI 701_ LMLQQ 706_ ERAGL 711_ QEEAQ 716_ QLRDE 721_ IEELN 726_ AAINL 731_ CQQQL 736_ PATGV 741_ PITHQ 746_ RFDQM 751_ RDMFD 756_ DYVRT 761_ RTLHN 766_ WKFWV 771_ FSILI 776_ RPLFE 781_ SFNGM 786_ VSTAS 791_ VHTLR 796_ QTSLA 801_ WLDQY 806_ CSLPA 811_ LRPTV 816_ LNSLR 821_ QLGTS 826_ TSILT 831_ DPGRI 836_ PEQAT 841_ RAVTE 846_GTLGK
1: Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity)