Ras-related protein Rab-18
1_MDEDV 6_ LTTLK 11_ ILIIG 16_ ESGVG 21_ KSSLL 26_ LRFTD 31_ DTFDP 36_ ELAAT 41_ IGVDF 46_ KVKTI 51_ SVDGN 56_ KAKLA 61_ IWDTA 66_ GQERF 71_ RTLTP 76_ SYYRG 81_ AQGVI 86_ LVYDV 91_ TRRDT 96_ FVKLD 101_ NWLNE 106_ LETYC 111_ TRNDI 116_ VNMLV 121_ GNKID 126_ KENRE 131_ VDRNE 136_ GLKFA 141_ RKHSM 146_ LFIEA 151_ SAKTC 156_ DGVQC 161_ AFEEL 166_ VEKII 171_ QTPGL 176_ WESEN 181_ QNKGV 186_ KLSHR 191_ EEGQG 196_ GGACG 201_GYCSV
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:24891604, PubMed:30970241). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:24891604, PubMed:30970241). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241). Also required for maintaining endoplasmic reticulum structure (PubMed:24891604). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985)