Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (EC 2.4.1.141) (EC 3.4.19.12) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) (UDP-N-acetylglucosamine transferase subunit ALG13 homolog)
1_MKCVF 6_ VTVGT 11_ TSFDD 16_ LIACV 21_ SAPDS 26_ LQKIE 31_ SLGYN 36_ RLILQ 41_ IGRGT 46_ VVPEP 51_ FSTES 56_ FTLDV 61_ YRYKD 66_ SLKED 71_ IQKAD 76_ LVISH 81_ AGAGS 86_ CLETL 91_ EKGKP 96_ LVVVI 101_ NEKLM 106_ NNHQL 111_ ELAKQ 116_ LHKEG 121_ HLFYC 126_ TCRVL 131_ TCPGQ 136_ AKSIA 141_ SAPGK 146_ CQDSA 151_ ALTST 156_ AFSGL 161_ DFGLL 166_ SGYLH 171_ KQALV 176_ TATHP 181_ TCTLL 186_ FPSCH 191_ AFFPL 196_ PLTPT 201_ LYKMH 206_ KGWKN 211_ YCSQK 216_ SLNEA 221_ SMDEY 226_ LGSLG 231_ LFRKL 236_ TAKDA 241_ SCLFR 246_ AISEQ 251_ LFCSQ 256_ VHHLE 261_ IRKAC 266_ VSYMR 271_ ENQQT 276_ FESYV 281_ EGSFE 286_ KYLER 291_ LGDPK 296_ ESAGQ 301_ LEIRA 306_ LSLIY 311_ NRDFI 316_ LYRFP 321_ GKPPT 326_ YVTDN 331_ GYEDK 336_ ILLCY 341_ SSSGH 346_ YDSVY 351_ SKQFQ 356_ SSAAV 361_ CQAVL 366_ YEILY 371_ KDVFV 376_ VDEEE 381_ LKTAI 386_ KLFRS 391_ GSKKN 396_ RNNAV 401_ TGSED 406_ AHTDY 411_ KSSNQ 416_ NRMEE 421_ WGACY 426_ NAENI 431_ PEGYN 436_ KGTEE 441_ TKSPE 446_ NPSKM 451_ PFPYK 456_ VLKAL 461_ DPEIY 466_ RNVEF 471_ DVWLD 476_ SRKEL 481_ QKSDY 486_ MEYAG 491_ RQYYL 496_ GDKCQ 501_ VCLES 506_ EGRYY 511_ NAHIQ 516_ EVGNE 521_ NNSVT 526_ VFIEE 531_ LAEKH 536_ VVPLA 541_ NLKPV 546_ TQVMS 551_ VPAWN 556_ AMPSR 561_ KGRGY 566_ QKMPG 571_ GYVPE 576_ IVISE 581_ MDIKQ 586_ QKKMF 591_ KKIRG 596_ KEVYM 601_ TMAYG 606_ KGDPL 611_ LPPRL 616_ QHSMH 621_ YGHDP 626_ PMHYS 631_ QTAGN 636_ VMSNE 641_ HFHPQ 646_ HPSPR 651_ QGRGY 656_ GMPRN 661_ SSRFI 666_ NRHNM 671_ PGPKV 676_ DFYPG 681_ PGKRC 686_ CQSYD 691_ NFSYR 696_ SRSFR 701_ RSHRQ 706_ MSCVN 711_ KESQY 716_ GFTPG 721_ NGQMP 726_ RGLEE 731_ TITFY 736_ EVEEG 741_ DETAY 746_ PTLPN 751_ HGGPS 756_ TMVPA 761_ TSGYC 766_ VGRRG 771_ HSSGK 776_ QTLNL 781_ EEGNG 786_ QSENG 791_ RYHEE 796_ YLYRA 801_ EPDYE 806_ TSGVY 811_ STTAS 816_ TANLS 821_ LQDRK 826_ SCSMS 831_ PQDTV 836_ TSYNY 841_ PQKMM 846_ GNIAA 851_ VAASC 856_ ANNVP 861_ APVLS 866_ NGAAA 871_ NQAIS 876_ TTSVS 881_ SQNAI 886_ QPLFV 891_ SPPTH 896_ GRPVI 901_ ASPSY 906_ PCHSA 911_ IPHAG 916_ ASLPP 921_ PPPPP 926_ PPPPP 931_ PPPPP 936_ PPPPP 941_ PPPPP 946_ ALDVG 951_ ETSNL 956_ QPPPP 961_ LPPPP 966_ YSCDP 971_ SGSDL 976_ PQDTK 981_ VLQYY 986_ FNLGL 991_ QCYYH 996_ SYWHS 1001_ MVYVP 1006_ QMQQQ 1011_ LHVEN 1016_ YPVYT 1021_ EPPLV 1026_ DQTVP 1031_ QCYSE 1036_ VRRED 1041_ GIQAE 1046_ ASAND 1051_ TFPNA 1056_ DSSSV 1061_ PHGAV 1066_ YYPVM 1071_ SDPYG 1076_ QPPLP 1081_ GFDSC 1086_ LPVVP 1091_ DYSCV 1096_ PPWHP 1101_ VGTAY 1106_ GGSSQ 1111_ IHGAI 1116_ NPGPI 1121_ GCIAP 1126_ SPPAS 1131_HYVPQ
1: Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway
2: Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway
3: No glycosyltransferase or deubiquitinase activity is detected for this potential multifunctional enzyme