Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1)
1_MAALA 6_ PLPPL 11_ PAQFK 16_ SIQHH 21_ LRTAQ 26_ EHDKR 31_ DPVVA 36_ YYCRL 41_ YAMQT 46_ GMKID 51_ SKTPE 56_ CRKFL 61_ SKLMD 66_ QLEAL 71_ KKQLG 76_ DNEAI 81_ TQEIV 86_ GCAHL 91_ ENYAL 96_ KMFLY 101_ ADNED 106_ RAGRF 111_ HKNMI 116_ KSFYT 121_ ASLLI 126_ DVITV 131_ FGELT 136_ DENVK 141_ HRKYA 146_ RWKAT 151_ YIHNC 156_ LKNGE 161_ TPQAG 166_ PVGIE 171_ EDNDI 176_ EENED 181_ AGAAS 186_ LPTQP 191_ TQPSS 196_ SSTYD 201_ PSNMP 206_ SGNYT 211_ GIQIP 216_ PGAHA 221_ PANTP 226_ AEVPH 231_ STGVA 236_ SNTIQ 241_ PTPQT 246_ IPAID 251_ PALFN 256_ TISQG 261_ DVRLT 266_ PEDFA 271_ RAQKY 276_ CKYAG 281_ SALQY 286_ EDVST 291_ AVQNL 296_ QKALK 301_LLTTG
1: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding