Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2)
1_MSINL 6_ TVDIY 11_ IYLLS 16_ NARSV 21_ CGKQR 26_ SKQLY 31_ FLFSP 36_ KHYWR 41_ ISHIS 46_ LQRGF 51_ HTNII 56_ RCKWT 61_ KSEAH 66_ SCSKH 71_ CYSPS 76_ NHGLH 81_ IGILK 86_ LSTSA 91_ PKGLT 96_ KVNIC 101_ MSRIK 106_ STLNS 111_ VSKAV 116_ FGNQN 121_ EMISR 126_ LAQFK 131_ PSSQI 136_ LRKVS 141_ DSGWL 146_ KQKNI 151_ KQAIK 156_ SLKKY 161_ SDKSA 166_ EKSPF 171_ PEEKS 176_ HIIDK 181_ EEDIG 186_ KRSLF 191_ HYTSS 196_ ITTKF 201_ GDSFY 206_ FLSNH 211_ INSYF 216_ KRKEK 221_ MSQQK 226_ ENEHF 231_ RDKSE 236_ LEDKK 241_ VEEGK 246_ LRSPD 251_ PGILA 256_ YKPGS 261_ ESVHT 266_ VDKPT 271_ SPSAI 276_ PDVLQ 281_ VSTKQ 286_ SIANF 291_ LSRPT 296_ EGVQA 301_ LVGGY 306_ IGGLV 311_ PKLKY 316_ DSKSQ 321_ SEEQE 326_ EPAKT 331_ DQAVS 336_ KDRNA 341_ EEKKR 346_ LSLQR 351_ EKIIA 356_ RVSID 361_ NRTRA 366_ LVQAL 371_ RRTTD 376_ PKLCI 381_ TRVEE 386_ LTFHL 391_ LEFPE 396_ GKGVA 401_ VKERI 406_ IPYLL 411_ RLRQI 416_ KDETL 421_ QAAVR 426_ EILAL 431_ IGYVD 436_ PVKGR 441_ GIRIL 446_ SIDGG 451_ GTRGV 456_ VALQT 461_ LRKLV 466_ ELTQK 471_ PVHQL 476_ FDYIC 481_ GVSTG 486_ AILAF 491_ MLGLF 496_ HMPLD 501_ ECEEL 506_ YRKLG 511_ SDVFS 516_ QNVIV 521_ GTVKM 526_ SWSHA 531_ FYDSQ 536_ TWENI 541_ LKDRM 546_ GSALM 551_ IETAR 556_ NPTCP 561_ KVAAV 566_ STIVN 571_ RGITP 576_ KAFVF 581_ RNYGH 586_ FPGIN 591_ SHYLG 596_ GCQYK 601_ MWQAI 606_ RASSA 611_ APGYF 616_ AEYAL 621_ GNDLH 626_ QDGGL 631_ LLNNP 636_ SALAM 641_ HECKC 646_ LWPDV 651_ PLECI 656_ VSLGT 661_ GRYES 666_ DVRNT 671_ VTYTS 676_ LKTKL 681_ SNVIN 686_ SATDT 691_ EEVHI 696_ MLDGL 701_ LPPDT 706_ YFRFN 711_ PVMCE 716_ NIPLD 721_ ESRNE 726_ KLDQL 731_ QLEGL 736_ KYIER 741_ NEQKM 746_ KKVAK 751_ ILSQE 756_ KTTLQ 761_ KINDW 766_ IKLKT 771_ DMYEG 776_LPFFS
1: Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors (PubMed:10744668, PubMed:10833412, PubMed:15695510, PubMed:15908428, PubMed:17213206, PubMed:18171998, PubMed:28442572). Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former (PubMed:15695510). Also has a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine (PubMed:10744668, PubMed:10833412, PubMed:15695510, PubMed:15908428). However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling (PubMed:15908428). On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates (PubMed:15908428). Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers (PubMed:15695510, PubMed:15908428). Can also hydrolyze lysophosphatidylcholine (PubMed:15695510). In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (PubMed:28442572)