Zinc transporter ZIP2 (6A1) (Eti-1) (Solute carrier family 39 member 2) (Zrt- and Irt-like protein 2) (ZIP-2) (hZIP2)
1_MEQLL 6_ GIKLG 11_ CLFAL 16_ LALTL 21_ GCGLT 26_ PICFK 31_ WFQID 36_ AARGH 41_ HRLVL 46_ RLLGC 51_ ISAGV 56_ FLGAG 61_ FMHMT 66_ AEALE 71_ EIESQ 76_ IQKFM 81_ VQNRS 86_ ASERN 91_ SSGDA 96_ DSAHM 101_ EYPYG 106_ ELIIS 111_ LGFFF 116_ VFFLE 121_ SLALQ 126_ CCPGA 131_ AGGST 136_ VQDEE 141_ WGGAH 146_ IFELH 151_ SHGHL 156_ PSPSK 161_ GPLRA 166_ LVLLL 171_ SLSFH 176_ SVFEG 181_ LAVGL 186_ QPTVA 191_ ATVQL 196_ CLAVL 201_ AHKGL 206_ VVFGV 211_ GMRLV 216_ HLGTS 221_ SRWAV 226_ FSILL 231_ LALMS 236_ PLGLA 241_ VGLAV 246_ TGGDS 251_ EGGRG 256_ LAQAV 261_ LEGVA 266_ AGTFL 271_ YVTFL 276_ EILPR 281_ ELASP 286_ EAPLA 291_ KWSCV 296_ AAGFA 301_FMAFI
1: Transporter for the divalent cation Zn(2+) (PubMed:10681536, PubMed:29791142, PubMed:30914478). Mediates the influx of Zn(2+) into cells from extracellular space. The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Also transports other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (PubMed:29791142, PubMed:30914478). In the skin, aids in the differentiation of keratinocytes in the epidermis (By similarity)