Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354)
1_MRKTR 6_ LWGLL 11_ WMLFV 16_ SELRA 21_ ATKLT 26_ EEKYE 31_ LKEGQ 36_ TLDVK 41_ CDYTL 46_ EKFAS 51_ SQKAW 56_ QIIRD 61_ GEMPK 66_ TLACT 71_ ERPSK 76_ NSHPV 81_ QVGRI 86_ ILEDY 91_ HDHGL 96_ LRVRM 101_ VNLQV 106_ EDSGL 111_ YQCVI 116_ YQPPK 121_ EPHML 126_ FDRIR 131_ LVVTK 136_ GFSGT 141_ PGSNE 146_ NSTQN 151_ VYKIP 156_ PTTTK 161_ ALCPL 166_ YTSPR 171_ TVTQA 176_ PPKST 181_ ADVST 186_ PDSEI 191_ NLTNV 196_ TDIIR 201_ VPVFN 206_ IVILL 211_ AGGFL 216_ SKSLV 221_ FSVLF 226_AVTLR
1: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:17568691, PubMed:25595774, PubMed:29568119). In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:14656437, PubMed:21659545). This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17098818, PubMed:17568691). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:11323674, PubMed:21393102)
2: Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its ligand