Calcium-activated potassium channel subunit beta-3 (BK channel subunit beta-3) (BKbeta3) (Hbeta3) (Calcium-activated potassium channel, subfamily M subunit beta-3) (Charybdotoxin receptor subunit beta-3) (K(VCA)beta-3) (Maxi K channel subunit beta-3) (Slo-beta-3)
1_MDFSP 6_ SSELG 11_ FHFVA 16_ FILLT 21_ RHRTA 26_ FPASG 31_ KKRET 36_ DYSDG 41_ DPLDV 46_ HKRLP 51_ SSAGE 56_ DRAVM 61_ LGFAM 66_ MGFSV 71_ LMFFL 76_ LGTTI 81_ LKPFM 86_ LSIQR 91_ EESTC 96_ TAIHT 101_ DIMDD 106_ WLDCA 111_ FTCGV 116_ HCHGQ 121_ GKYPC 126_ LQVFV 131_ NLSHP 136_ GQKAL 141_ LHYNE 146_ EAVQI 151_ NPKCF 156_ YTPKC 161_ HQDRN 166_ DLLNS 171_ ALDIK 176_ EFFDH 181_ KNGTP 186_ FSCFY 191_ SPASQ 196_ SEDVI 201_ LIKKY 206_ DQMAI 211_ FHCLF 216_ WPSLT 221_ LLGGA 226_ LIVGM 231_ VRLTQ 236_ HLSLL 241_ CEKYS 246_ TVVRD 251_ EVGGK 256_ VPYIE 261_ QHQFK 266_ LCIMR 271_RSKGR
1: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer