Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog)
1_MVVSK 6_ MNKDA 11_ QMRAA 16_ INQKL 21_ IETGE 26_ RERLK 31_ ELLRA 36_ KLIEC 41_ GWKDQ 46_ LKAHC 51_ KEVIK 56_ EKGLE 61_ HVTVD 66_ DLVAE 71_ ITPKG 76_ RALVP 81_ DSVKK 86_ ELLQR 91_ IRTFL 96_AQHAS
1: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820)