5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)
1_MIRLG 6_ GWCAR 11_ RLCSA 16_ AVPAG 21_ RRGAA 26_ GGLGL 31_ AGGRA 36_ LRVLV 41_ DMDGV 46_ LADFE 51_ GGFLR 56_ KFRAR 61_ FPDQP 66_ FIALE 71_ DRRGF 76_ WVSEQ 81_ YGRLR 86_ PGLSE 91_ KAISI 96_ WESKN 101_ FFFEL 106_ EPLPG 111_ AVEAV 116_ KEMAS 121_ LQNTD 126_ VFICT 131_ SPIKM 136_ FKYCP 141_ YEKYA 146_ WVEKY 151_ FGPDF 156_ LEQIV 161_ LTRDK 166_ TVVSA 171_ DLLID 176_ DRPDI 181_ TGAEP 186_ TPSWE 191_ HVLFT 196_ ACHNQ 201_ HLQLQ 206_ PPRRR 211_ LHSWA 216_ DDWKA 221_ILDSK
1: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP